The Early Onset of Levodopa-induced Dyskinesia in a Patient with Multiple System Atrophy

Multiple system atrophy (MSA) is a neurodegenerative disorder characterized by Parkinsonism, cerebellar ataxia, and autonomic dysfunction. While less frequent than Parkinson's disease, MSA patients with a beneficial levodopa response may occasionally present with levodopa-induced dyskinesia (LI...

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Bibliographic Details
Published in:Internal Medicine 2024/09/01, Vol.63(17), pp.2451-2453
Main Authors: Okusa, Shohei, Nakahara, Jin, Seki, Morinobu
Format: Article
Language:English
Subjects:
Atrophy
Autonomic nervous system
Basal ganglia
Case Report
Central nervous system diseases
Cerebellar ataxia
Cerebellum
Dyskinesia
Levodopa
levodopa-induced dyskinesia
Movement disorders
multiple system atrophy
Neurodegenerative diseases
Parkinson's disease
parkinsonism
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Summary:Multiple system atrophy (MSA) is a neurodegenerative disorder characterized by Parkinsonism, cerebellar ataxia, and autonomic dysfunction. While less frequent than Parkinson's disease, MSA patients with a beneficial levodopa response may occasionally present with levodopa-induced dyskinesia (LID). We herein report a 50-year-old woman diagnosed with MSA-parkinsonism who developed LID in the unilateral lower extremity 10 months after the start of levodopa treatment. In this case, the distribution of LID, the timing of its onset, and the presence of LID despite relatively poor levodopa responsiveness were distinctive.
ISSN:0918-2918
1349-7235
1349-7235
DOI:10.2169/internalmedicine.3058-23