Bio-conversion of organic wastes towards polyhydroxyalkanoates

• Published in: Biotechnology Notes 2023-01, Vol.4, p.118-126
• Main Authors: Kuang, Zhe-Yi, Yang, Hao, Shen, Shi-Wei, Lin, Yi-Na, Sun, Shu-Wen, Neureiter, Markus, Yue, Hai-Tao, Ye, Jian-Wen
• Format: Article
• Language: English
• ISSN: 2665-9069; 2665-9069
• DOI: 10.1016/j.biotno.2023.11.006

The bio-manufacturing of products with substantial commercial value, particularly polyhydroxyalkanoates (PHA), using cost-effective carbon sources through microorganisms, has garnered heightened attention from both the scientific community and industry over the past few decades. Opting for industrial PHA production from various organic wastes, spanning industrial, agricultural, municipal, and food-based sources, emerges as a wiser choice. This strategy not only eases the burden of recycling organic waste and curbs environmental pollution but also trims down PHA production costs, rendering these materials more competitive in commercial markets. In addition, PHAs are a family of renewable, environmentally friendly, fully biodegradable and biocompatible polyesters with a multitude of applications. This review provides an overview of recent developments in PHA production from organic wastes. It covers the optimization of diverse metabolic pathways for producing various types of PHA from organic waste sources, pre-treatment and downstream processing for PHA using unrelated organic wastes, and challenges in industrial production of PHA using unrelated organic waste feedstocks and the challenges faced in industrial PHA production from organic wastes, along with potential solutions. Lastly, this study suggests underlying research endeavors aimed at further enhancing of the feasibility of industrial PHA production from organic wastes as an alternative to current petroleum-based plastics in the near future.