Evaluation of circulating immune cells, analytes, and inflammatory markers in sows affected with postpartum dysgalactia syndrome

• Published in: Journal of animal science 2024-01, Vol.102
• Main Authors: Studer, Jamie M, Kiefer, Zoë E, Koester, Lucas R, Johnson, Erika M, Schmitz-Esser, Stephan, Farkas, Attila, Galina Pantoja, Lucina, Vonnahme, Kimberly A, Greiner, Laura L, Keating, Aileen F, Baumgard, Lance H, Ross, Jason W
• Format: Article
• Language: English
• Subjects: Animals; Biomarkers - blood; Colostrum - immunology; Female; Inflammation - blood; Inflammation - veterinary; Lactation; Lactation and Mammary Gland Biology; Lactation Disorders - blood; Lactation Disorders - veterinary; Milk - chemistry; Postpartum Period; Pregnancy; Swine; Swine Diseases - blood; Swine Diseases - immunology
• ISSN: 0021-8812; 1525-3163; 1525-3163
• DOI: 10.1093/jas/skae270

Postpartum dysgalactia syndrome (PDS) is a condition affecting periparturient sows, characterized by a reduction in milk and colostrum synthesis shortly after farrowing. Insufficient milk production results in substantial economic losses due to increased piglet morbidity/mortality and premature sow culling. Since PDS develops within a few days following farrowing, the study objectives were to determine if periparturient immune cell profiles and circulating biomarkers differ in sows affected by PDS. We hypothesized differences in immune cells, circulating analytes, and inflammatory markers would exist at farrowing in sows that subsequently developed PDS compared to healthy herd-mates. Thirty-six sows with PDS symptoms were matched by parity and day of lactation with 36 healthy control (CON) sows. Diagnosis of PDS (timepoint 2) occurred on average 9.25 ± 2.67 d after farrowing. Blood samples and litter weights were collected at farrowing (timepoint 1) and at the onset of clinical PDS (timepoint 2). Piglets from PDS sows had lower average daily gain and higher mortality than piglets from CON (P