8423 Pattern of Thyroid Function Tests Variation Among an Elderly Population

• Published in: Journal of the Endocrine Society 2024-10, Vol.8 (Supplement_1)
• Main Authors: Izabel Chiamolera, Maria, Morgado, Jose P M, Ferrer, Claudia M A F, Eulalio Pereira, Otavio Jose, Lima, Jose Viana, Saddi, Pedro R, Gilberto Vieira, Jose, Maciel, Rui M B, Mello Biscolla, Rosa Paula
• Format: Article
• Language: English
• Subjects: Abstract
• ISSN: 2472-1972; 2472-1972
• DOI: 10.1210/jendso/bvae163.2035

Abstract Disclosure: M.I. Chiamolera: Employee; Self; Fleury Medicina e Saude. J.P. Morgado: Employee; Self; Fleury Medicina e Saude. C.M. Ferrer: Employee; Self; Fleury Medicina e Saude. O.J. Pereira: Employee; Self; Grupo Fleury. J.V. Lima: Employee; Self; Fleury Medicina e Saude. P.R. Saddi: Employee; Self; Fleury Medicina e Saude. J.G. Vieira: Owner/Co-Owner; Self; Fleury Medicina e Saude. R.M. Maciel: Owner/Co-Owner; Self; Fleury Medicina e Saude. R.M. Biscolla: Employee; Self; Fleury Medicina e Saude. Introduction: The understanding of thyroid function data has evolved in recent decades, revealing a consistent rise in age-related TSH levels as demonstrated by various research groups. The advent of Big Data, marked by an abundance of studies with expansive datasets, has mitigated the former limitations of sample sizes. Consequently, utilizing clinical laboratory databases to study the behavior of these tests has emerged as a feasible and innovative solution.Objective: This study aims to investigate the patterns of TSH and free T4 (fT4) levels in a population aged 60 years and above. The analysis utilizes thyroid function test database from Latin American lab. Methods: A retrospective analysis was conducted on data from 8,694,807 blood samples, initially filtering for TSH analysis based on criteria such as concentration within the reference values of fT4, absence of negative anti-thyroid antibodies, and no medication usage. The TSH assays were performed in a Roche Platform, and fT4 assays were performed in Roche, Beckman and Siemens platforms. Statistical analyses were achieved using Shapiro-Wilk, Kruskal-Wallis, Dunn´s post-hoc test, Cohen´s D test, and others. Results: From the initial group, 439,690 TSH samples, 79,928 Beckman fT4 (fT1b), 35,623 Siemens fT4 (fT4s) and 324,139 fT4 (fT4r) were selected to be studied. TSH analyses using the Kruskal-Wallis test (KWT) showed a difference between age groups (p-value