6939 Do an empty sella and a partial empty sella affect the modeling and displacement of the optic chiasm?

• Published in: Journal of the Endocrine Society 2024-10, Vol.8 (Supplement_1)
• Main Authors: Kaluza, Bernadetta, Furmanek, Mariusz, Domanski, Jan, Zuk-Lapan, Aleksandra, Babula, Emilia, Iga, Poprawa, Landowska, Malgorzata, Jarzabek, Karolina, Popczynska, Justyna, Filipowicz, Paulina, Wielgolewska, Malgorzata, Walecki, Jerzy, Franek, Edward M
• Format: Article
• Language: English
• Subjects: Abstract
• ISSN: 2472-1972; 2472-1972
• DOI: 10.1210/jendso/bvae163.1192

Abstract Disclosure: B. Kaluza: None. M. Furmanek: None. J. Domanski: None. A. Zuk-Lapan: None. E. Babula: None. P. Iga: None. M. Landowska: None. K. Jarzabek: None. J. Popczynska: None. P. Filipowicz: None. M. Wielgolewska: None. J. Walecki: None. E.M. Franek: None. An empty sella and a partial empty sella are a result of the bulging of the subarachnoid space into the sella turcica. Primary empty sella has no tangible cause, while secondary empty sella is due to a pathology in the central nervous system, which may be manifested as visual disorders occurring via optic chiasm modeling or displacement. The aim of the study was to determine whether an empty sella and a partial empty sella, both primary and secondary, were the risk factors for modeling the optic chiasm. In order to conduct the study, the hospital database was analyzed and 891 patients who had undergone pituitary and CNS MRI were selected. An empty sella and a partial empty sella were confirmed in 212 patients, of which 157 patients had a primary and 55 had a secondary form. Compression and modeling of the optic chiasm were found in 29 patients. Univariate logistic regression showed that the predictors of compression and modeling of the optic chiasm included: the presence of a pituitary adenoma (OR 2.275, 95% Cl 1.083-4.779, p=0.03) - especially macroadenoma (OR 29.472, [10.751-80.789], p=0.0001) and a status post CNS surgery (OR 10.226, [1.031-101.418], p=0.047). Conversely, an empty and partial empty sella (OR 1.02, [0.429-2.422], p=0.965) - both primary (0.741, [0.254-2.161], p= 0.584) and secondary (1.193, [0.353-4.034], p=0.776), as well as Rathke cleft cyst (OR 0.517,[0.121-2.206], p=0.373) and a pituitary cyst (OR 0.789, [0.184-3.383], p=0.749) were not found to play such a role. An empty and partial empty sella do not affect the modeling and displacement of the optic chiasm, so they may not contribute to visual symptoms such as the narrowing the visual field and diplopia. Presentation: 6/3/2024