Predictive role of systemic immune-inflammation index and neutrophil/lymphocyte ratio values in infants with retinopathy of prematurity

• Published in: Graefe's archive for clinical and experimental ophthalmology 2024-10, Vol.262 (10), p.3125-3134
• Main Authors: Oruz, Oğuzhan, Dervişoğulları, Mehmet Serdar, Öktem, Müzeyyen Ezgi, İncekaş, Caner
• Format: Article
• Language: English
• Subjects: Female; Follow-Up Studies; Gestational Age; Humans; Infant, Newborn; Infant, Premature; Infants; Inflammation; Inflammation - diagnosis; Lasers; Leukocytes (neutrophilic); Lymphocytes; Male; Medicine; Medicine & Public Health; Monocytes; Neutrophils; Ophthalmology; Postpartum period; Predictive Value of Tests; Prognosis; Retinal Disorders; Retinopathy; Retinopathy of Prematurity - blood; Retinopathy of Prematurity - diagnosis; Retinopathy of Prematurity - surgery; Retrospective Studies; Risk Factors
• ISSN: 0721-832X; 1435-702X; 1435-702X
• DOI: 10.1007/s00417-024-06493-y

Purpose To search the relationship between serum neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and systemic immune-inflammation index (SII) values with the development of retinopathy of prematurity (ROP) and the requirement for laser treatment. Methods This retrospective cohort study was carried out with 195 preterm infants between 2012 and 2023. The NLR, PLR, LMR, and SII values were calculated on both the first day and at the end of the first month after birth. The association between development of ROP and other risk factors were analyzed using univariate analysis and multivariate logistic regression analysis. Results Of patients, 92 infants were diagnosed with ROP. Laser treatment was administered to 36 infants. The postnatal first-day NLR and SII values were higher in infants with ROP than in infants without ROP (p