Assessing Per- and Polyfluoroalkyl Substances in Fish Fillet Using Non-Targeted Analyses

Per- and polyfluoroalkyl substances (PFAS) are a class of thousands of man-made chemicals that are persistent and highly stable in the environment. Fish consumption has been identified as a key route of PFAS exposure for humans. However, routine fish monitoring targets only a handful of PFAS, and no...

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Bibliographic Details
Published in:Environmental science & technology 2024-08, Vol.58 (32), p.14486-14495
Main Authors: Boatman, Anna K., Chappel, Jessie R., Polera, Madison E., Dodds, James N., Belcher, Scott M., Baker, Erin S.
Format: Article
Language:English
Subjects:
Drinking water
Fillets
Fish
Ionic mobility
Liquid chromatography
Mass spectrometry
Mass spectroscopy
Occurrence, Fate, and Transport of Aquatic and Terrestrial Contaminants
Perfluoroalkyl & polyfluoroalkyl substances
Perfluorochemicals
Perfluorooctane sulfonic acid
Recreational waters
Scientific imaging
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Summary:Per- and polyfluoroalkyl substances (PFAS) are a class of thousands of man-made chemicals that are persistent and highly stable in the environment. Fish consumption has been identified as a key route of PFAS exposure for humans. However, routine fish monitoring targets only a handful of PFAS, and non-targeted analyses have largely only evaluated fish from heavily PFAS-impacted waters. Here, we evaluated PFAS in fish fillets from recreational and drinking water sources in central North Carolina to assess whether PFAS are present in these fillets that would not be detected by conventional targeted methods. We used liquid chromatography, ion mobility spectrometry, and mass spectrometry (LC-IMS-MS) to collect full scan feature data, performed suspect screening using an in-house library of 100 PFAS for high confidence feature identification, searched for additional PFAS features using non-targeted data analyses, and quantified perfluorooctanesulfonic acid (PFOS) in the fillet samples. A total of 36 PFAS were detected in the fish fillets, including 19 that would not be detected using common targeted methods, with a minimum of 6 and a maximum of 22 in individual fish. Median fillet PFOS levels were concerningly high at 11.6 to 42.3 ppb, and no significant correlation between PFOS levels and number of PFAS per fish was observed. Future PFAS monitoring in this region should target more of these 36 PFAS, and other regions not considered heavily PFAS contaminated should consider incorporating non-targeted analyses into ongoing fish monitoring studies.
ISSN:0013-936X
1520-5851
1520-5851
DOI:10.1021/acs.est.4c04299