Marrow hypoplasia with splenomegaly in adolescence

Four adolescents presented with leucopenia, thrombocytopenia, and splenomegaly; three had associated congenital abnormalities and two had a cirrhosis. They provide further evidence of an association between hepatic disease and bone marrow dysfunction. It is considered that these patients suffer from...

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Bibliographic Details
Published in:Journal of clinical pathology 1980-08, Vol.33 (8), p.730-734
Main Authors: Robertson, J H, Burnside, P, Salmon, D C
Format: Article
Language:English
Subjects:
Adolescent
Adult
Bone Marrow - pathology
Bone Marrow Diseases - etiology
Bone Marrow Diseases - pathology
Female
Humans
Leukopenia - etiology
Liver Diseases - complications
Male
Splenomegaly - etiology
Thrombocytopenia - etiology
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Summary:Four adolescents presented with leucopenia, thrombocytopenia, and splenomegaly; three had associated congenital abnormalities and two had a cirrhosis. They provide further evidence of an association between hepatic disease and bone marrow dysfunction. It is considered that these patients suffer from a genetic or constitutional disorder which may result in a susceptibility of their bone marrow to hypoplasia following viral hepatitis or other infections.
ISSN:0021-9746
1472-4146
DOI:10.1136/jcp.33.8.730