Comparative analysis of clinical profile, laboratory profile and outcome in COVID-19 patients with and without hypothyroidism

• Published in: Ghana medical journal 2024-09, Vol.58 (3), p.192-197
• Main Authors: Malini B, Sindhu, Chidambaram, Yoganathan, Jenil Dhas C P, Clement, B K, Navinkumar, Kumar S, Sujith
• Format: Article
• Language: English
• Subjects: Original
• ISSN: 0016-9560; 2616-163X
• DOI: 10.4314/gmj.v58i3.3

Objectives: Previous studies suggest that patients’ thyroid status might directly impact the course of Coronavirus disease 2019 (COVID-19). The objective of the study was to determine the clinical profile of COVID-19 patients with hypothyroidism and compare it with that of COVID-19 patients without hypothyroidism.Design: Retrospective observational studySetting: The study was conducted in a tertiary healthcare centre in Tamil Nadu between May and June 2021.Participants: The study included 117 patients admitted with hypothyroidism and COVID-19 as well as 117 age and Gender matched COVID-19 patients without hypothyroidism.Main outcome measures: Data regarding the demography, comorbidities, presenting symptoms, method of diagnosis of COVID-19, computed tomography (CT) severity score, Interleukin 6 (IL-6), D-dimer, oxygen requirement, number of days in hospital and outcome were collected for both groups. Data analysis was conducted, and p0.05) between both groups. The outcomes also showed that both groups reported four mortalities.Conclusions: The results of the study help conclude that the hypothyroidism status of a COVID-19 patient is not associated with higher severity of clinical symptoms, deranged laboratory values as well as mortality.