In Vitro Mineralization of Collagen

Collagen mineralization is a biological process in many skeletal elements in the animal kingdom. Examples of these collagen‐based skeletons are the siliceous spicules of glass sponges or the intrafibrillar hydroxyapatite platelets in vertebrates. The mineralization of collagen in vitro has gained in...

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Bibliographic Details
Published in:Advanced materials (Weinheim) 2021-04, Vol.33 (16), p.e2004418-n/a
Main Authors: Oosterlaken, Bernette Maria, Vena, Maria Paula, With, Gijsbertus
Format: Article
Language:English
Subjects:
Animals
bioinspired materials
Biological activity
Calcification, Physiologic
Collagen
Collagen - chemistry
Collagen - metabolism
Durapatite - chemistry
Humans
Hydroxyapatite
Materials science
Mineralization
Minerals
Platelets
Review
Reviews
Scaffolds
silica
Silicon dioxide
Silicon Dioxide - chemistry
Spicules
Tissue engineering
Tissue Engineering - methods
Tissue Scaffolds - chemistry
Vertebrates
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Summary:Collagen mineralization is a biological process in many skeletal elements in the animal kingdom. Examples of these collagen‐based skeletons are the siliceous spicules of glass sponges or the intrafibrillar hydroxyapatite platelets in vertebrates. The mineralization of collagen in vitro has gained interest for two reasons: understanding the processes behind bone formation and the synthesis of scaffolds for tissue engineering. In this paper, the efforts toward collagen mineralization in vitro are reviewed. First, general introduction toward collagen type I, the main component of the extracellular matrix in animals, is provided, followed by a brief overview of collagenous skeletons. Then, the in vitro mineralization of collagen is critically reviewed. Due to their biological abundance, hydroxyapatite and silica are the focus of this review. To a much lesser extent, also some efforts with other minerals are outlined. Combining all minerals and the suggested mechanisms for each mineral, a general mechanism for the intrafibrillar mineralization of collagen is proposed. This review concludes with an outlook for further improvement of collagen‐based tissue engineering scaffolds. The in vitro mineralization of collagen deals with the mechanisms of bone formation and the synthesis of tissue engineering scaffolds. Due to their biological relevance, the extra‐ and intrafibrillar mineralization of collagen with hydroxyapatite and silica are the focus of this review. A general mechanism for the intrafibrillar mineralization of collagen is proposed.
ISSN:0935-9648
1521-4095
1521-4095
DOI:10.1002/adma.202004418