Polymer‐Based mRNA Delivery Strategies for Advanced Therapies

Messenger RNA (mRNA)‐based therapies offer great promise for the treatment of a variety of diseases. In 2020, two FDA approvals of mRNA‐based vaccines have elevated mRNA vaccines to global recognition. However, the therapeutic capabilities of mRNA extend far beyond vaccines against infectious diseas...

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Bibliographic Details
Published in:Advanced healthcare materials 2023-06, Vol.12 (15), p.e2202688-n/a
Main Authors: Yang, Wenqian, Mixich, Lucas, Boonstra, Eger, Cabral, Horacio
Format: Article
Language:English
Subjects:
Cancer Vaccines
Design criteria
Genetic modification
Genetic Therapy
Genome editing
Immunotherapy
Infectious diseases
ligand‐mediated targeting
Lipids
Materials science
messenger RNA
mRNA
Nanoparticles
Nanoparticles - chemistry
Pharmacokinetics
Polymers
Polymers - chemistry
polymer‐based delivery systems
Review
Reviews
Ribonucleic acid
RNA
RNA, Messenger - genetics
RNA, Messenger - metabolism
RNA, Messenger - therapeutic use
Stability criteria
System effectiveness
Tissue Distribution
Vaccines
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Summary:Messenger RNA (mRNA)‐based therapies offer great promise for the treatment of a variety of diseases. In 2020, two FDA approvals of mRNA‐based vaccines have elevated mRNA vaccines to global recognition. However, the therapeutic capabilities of mRNA extend far beyond vaccines against infectious diseases. They hold potential for cancer vaccines, protein replacement therapies, gene editing therapies, and immunotherapies. For realizing such advanced therapies, it is crucial to develop effective carrier systems. Recent advances in materials science have led to the development of promising nonviral mRNA delivery systems. In comparison to other carriers like lipid nanoparticles, polymer‐based delivery systems often receive less attention, despite their unique ability to carefully tune their chemical features to promote mRNA protection, their favorable pharmacokinetics, and their potential for targeting delivery. In this review, the central features of polymer‐based systems for mRNA delivery highlighting the molecular design criteria, stability, and biodistribution are discussed. Finally, the role of targeting ligands for the future of RNA therapies is analyzed. Messenger RNA (mRNA) has emerged as a powerful and versatile platform for treating different diseases. Polymer‐based nanovectors exhibit distinct advantages for mRNA delivery, though they still present several challenges for breaking into the mainstream. This review provides insights on polymeric carriers for constructing efficient mRNA delivery platforms toward future therapies.
ISSN:2192-2640
2192-2659
2192-2659
DOI:10.1002/adhm.202202688