Thiyl free radicals and the oxidation of ferrocytochrome c. Direct observation of coupled hydrogen-atom- and electron-transfer reactions

Absolute rate constants for the reaction of ferrocytochrome c with the thiyl radicals derived from cysteine, GSH, penicillamine and N-(2-mercaptopropionyl)glycine were measured by using the technique of pulse radiolysis. The reaction is believed to occur through a one-electron-transfer process, in a...

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Bibliographic Details
Published in:Biochemical journal 1986-12, Vol.240 (3), p.905-907
Main Authors: Forni, L G, Willson, R L
Format: Article
Language:English
Subjects:
Cytochrome c Group - metabolism
Electron Transport
Free Radicals
Kinetics
Oxidation-Reduction
Pulse Radiolysis
Sulfhydryl Compounds - metabolism
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Summary:Absolute rate constants for the reaction of ferrocytochrome c with the thiyl radicals derived from cysteine, GSH, penicillamine and N-(2-mercaptopropionyl)glycine were measured by using the technique of pulse radiolysis. The reaction is believed to occur through a one-electron-transfer process, in agreement with the hypothesis that thiols may act as catalysts linking hydrogen-atom- and electron-transfer reactions.
ISSN:0264-6021
1470-8728
DOI:10.1042/bj2400905