All‐Inorganic Polyoxometalates Act as Superchaotropic Membrane Carriers

Polyoxometalates (POMs) are known antitumoral, antibacterial, antiviral, and anticancer agents and considered as next‐generation metallodrugs. Herein, a new biological functionality in neutral physiological media, where selected mixed‐metal POMs are sufficiently stable and able to affect membrane tr...

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Bibliographic Details
Published in:Advanced materials (Weinheim) 2024-01, Vol.36 (1), p.e2309219-n/a
Main Authors: Barba‐Bon, Andrea, Gumerova, Nadiia I., Tanuhadi, Elias, Ashjari, Maryam, Chen, Yao, Rompel, Annette, Nau, Werner M.
Format: Article
Language:English
Subjects:
Anions
Anticancer properties
Antineoplastic Agents - chemistry
Biological effects
Biomedical materials
chaotropic carriers
delivery
Keggin anions
Materials science
membrane transport
Membranes
Metals
Peptides
Polyoxometallates
POM stability
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Summary:Polyoxometalates (POMs) are known antitumoral, antibacterial, antiviral, and anticancer agents and considered as next‐generation metallodrugs. Herein, a new biological functionality in neutral physiological media, where selected mixed‐metal POMs are sufficiently stable and able to affect membrane transport of impermeable, hydrophilic, and cationic peptides (heptaarginine, heptalysine, protamine, and polyarginine) is reported. The uptake is observed in both, model membranes as well as cells, and attributed to the superchaotropic properties of the polyoxoanions. In view of the structural diversity of POMs these findings pave the way toward their biomedical application in drug delivery or for cell‐biological uptake studies with biological effector molecules or staining agents. Inorganic anions of the polyoxometalate type display a new biological activity: They efficiently transport cationic peptides across lipidic and cellular membranes. This function is related to their superchaotropic nature, resulting in strong and concomitant interactions with peptides and lipids. Mixed‐metal Keggin‐type anions show the required hydrolytic stability and sufficiently low charge density that are prerequisites for the desirable carrier utility.
ISSN:0935-9648
1521-4095
1521-4095
DOI:10.1002/adma.202309219