The Potential Role of Reactive Oxygen Species Produced by Low-Density Neutrophils in Periodontitis

Neutrophils own an arsenal of dischargeable chemicals that enable them to handle bacterial challenges, manipulating innate immune response and actual participation in acquired immunity. The reactive oxygen species (ROS) are one of the most important chemicals that neutrophils discharge to eradicate...

Full description

Saved in:
Bibliographic Details
Published in:European journal of dentistry 2024-10, Vol.18 (4), p.1142-1148
Main Authors: Mousa, Ali Omran, Al Hussaini, Ali Hussien Abass, Hussein, Hashim Mueen
Format: Article
Language:English
Subjects:
Original
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Neutrophils own an arsenal of dischargeable chemicals that enable them to handle bacterial challenges, manipulating innate immune response and actual participation in acquired immunity. The reactive oxygen species (ROS) are one of the most important chemicals that neutrophils discharge to eradicate pathogens. Despite their beneficial role, the ROS were strongly correlated to periodontal tissue destruction. Lowdensity neutrophils (LDN) have been recognized for producing enhanced quantities of ROS. However, the potential role of ROS produced by LDN in periodontitis is unknown. The aim of the study was to investigate the impact of ROS produced by LDN in periodontal diseases.  Venous blood and periodontal parameters were obtained from 100 systemically healthy subjects divided into 40 participants with healthy periodontium in the control group and 60 with unstable periodontitis in the study group. Flow cytometry was used to measure the production of ROS by LDN in both groups.  The data were analyzed for normal distribution using the Shapiro-Wilk test at  
ISSN:1305-7456
1305-7464
DOI:10.1055/s-0044-1782211