Viral imitation is the sincerest form of epigenetic flattery

Viruses use multiple strategies to successfully generate progeny and overcome host defenses. In recent years, it has become increasingly evident that epigenetic mechanisms of host gene regulation are vulnerable to viral manipulation. In the form of histone mimicry, viral invasion of host chromatin i...

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Bibliographic Details
Published in:Molecular biology of the cell 2024-10, Vol.35 (10), p.pe3
Main Authors: Smith, Julian R, Arellano, Angela A, Avgousti, Daphne C
Format: Article
Language:English
Subjects:
Animals
Cell Biology of Infection
Chromatin - metabolism
COVID-19 - virology
Epigenesis, Genetic
Histones - metabolism
Host-Pathogen Interactions
Humans
Immune Evasion
Influenza A virus - genetics
Influenza A virus - physiology
SARS-CoV-2 - physiology
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Summary:Viruses use multiple strategies to successfully generate progeny and overcome host defenses. In recent years, it has become increasingly evident that epigenetic mechanisms of host gene regulation are vulnerable to viral manipulation. In the form of histone mimicry, viral invasion of host chromatin is a striking example of how viruses have evolved to invade every aspect of cellular function for viral benefit. In this perspective, we will review how three viruses-influenza A, SARS-CoV-2, and bracovirus-use histone mimicry to promote viral success through immune evasion. These examples highlight the importance of this burgeoning field and point toward the wealth of knowledge we have yet to uncover.
ISSN:1059-1524
1939-4586
1939-4586
DOI:10.1091/mbc.E23-04-0147