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Toxic effects of ozone on murine L929 fibroblasts. Damage to DNA

Damage to DNA caused by exposure of L929 fibroblasts to ozone was reflected by the generation of strand breaks, DNA inter-strand cross-links and DNA-protein cross-links. Addition of propan-2-ol, a hydroxyl radical scavenger, did not affect the formation of strand breaks. In model experiments it appe...

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Bibliographic Details
Published in:Biochemical journal 1987-10, Vol.247 (1), p.69-72
Main Authors: Van der Zee, J, Van Beek, E, Dubbelman, T M, Van Steveninck, J
Format: Article
Language:English
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Summary:Damage to DNA caused by exposure of L929 fibroblasts to ozone was reflected by the generation of strand breaks, DNA inter-strand cross-links and DNA-protein cross-links. Addition of propan-2-ol, a hydroxyl radical scavenger, did not affect the formation of strand breaks. In model experiments it appeared that both purines and pyrimidines were involved in DNA inter-strand and DNA-protein cross-links.
ISSN:0264-6021
1470-8728
DOI:10.1042/bj2470069