More than one shade of pink as a marker of early amelanotic/hypomelanotic melanoma

Amelanotic/hypomelanotic melanoma (AHM) may be difficult to diagnose because of a lack of pigmentation. To evaluate whether dermoscopy can be useful for the diagnosis of early AHM, 133 digital dermoscopic images of lesions histopathologically diagnosed as amelanotic/hypomelanotic superficial spreadi...

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Bibliographic Details
Published in:Journal of dermatology 2024-07, Vol.51 (7), p.999-1003
Main Authors: Pizzichetta, M. A., Corsetti, P., Stanganelli, I., Ghigliotti, G., Cavicchini, S., De Giorgi, V., Bono, R., Astorino, S., Ribero, S., Argenziano, G., Alaibac, Polesel, J.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
amelanotic melanoma
Basal cell carcinoma
benign melanocytic lesion
Carcinoma, Basal Cell - diagnosis
Carcinoma, Basal Cell - diagnostic imaging
Carcinoma, Basal Cell - pathology
Concise Communication
Dermoscopy
Diagnosis, Differential
Female
Humans
Keratosis
Lesions
Male
Melanoma
Melanoma - diagnosis
Melanoma - diagnostic imaging
Melanoma - pathology
Melanoma, Amelanotic - diagnosis
Melanoma, Amelanotic - pathology
Middle Aged
Multivariate analysis
non‐melanocytic lesion
Pigmentation
Retrospective Studies
Shade
Skin - diagnostic imaging
Skin - pathology
Skin Neoplasms - diagnosis
Skin Neoplasms - diagnostic imaging
Skin Neoplasms - pathology
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Summary:Amelanotic/hypomelanotic melanoma (AHM) may be difficult to diagnose because of a lack of pigmentation. To evaluate whether dermoscopy can be useful for the diagnosis of early AHM, 133 digital dermoscopic images of lesions histopathologically diagnosed as amelanotic/hypomelanotic superficial spreading melanoma with ≤1 mm thickness (AHSSMs) (n = 27), amelanotic/hypomelanotic non‐melanocytic lesions (AHNMLs) (e.g., seborrhoeic keratosis and basal cell carcinoma) (n = 79), and amelanotic/hypomelanotic benign melanocytic lesions (AHBMLs) (e.g., compound and dermal nevi) (n = 27), were dermoscopically assessed by three blinded dermatologists. Using multivariate analysis, we found a significantly increased risk of diagnosing AHSSM versus AHNML and AHBML when the lesion was characterized by the presence of more than one shade of pink (odds ratio [OR] 37.11), irregular dots/globules (OR 23.73), asymmetric pigmentation (OR 8.85), and structureless pattern (OR 7.33). In conclusion, dermoscopy may improve early AHM detection, discriminating AHSSM from amelanotic/hypomelanotic non melanoma lesions.
ISSN:0385-2407
1346-8138
1346-8138
DOI:10.1111/1346-8138.17200