Management of Renovascular Hypertension and Renal Denervation in Patients with Hypertension: An Italian Nationwide Survey

• Published in: High blood pressure & cardiovascular prevention 2024-09, Vol.31 (5), p.501-512
• Main Authors: Pappaccogli, Marco, Ponsa, Lara, Goi, Jessica, Burrello, Jacopo, Di Dalmazi, Guido, Cicero, Arrigo Francesco Giuseppe, Mancusi, Costantino, Moia, Elena Coletti, Iaccarino, Guido, Borghi, Claudio, Muiesan, Maria Lorenza, Ferri, Claudio, Rabbia, Franco, Mulatero, Paolo
• Format: Article
• Language: English
• Subjects: Atherosclerosis; Blood pressure; Cardiology; Cardiovascular disease; Denervation; Heart failure; Hypertension; Internal medicine; Kidney diseases; Medicine; Original; Patients; Polls & surveys; Questionnaires
• ISSN: 1120-9879; 1179-1985
• DOI: 10.1007/s40292-024-00668-8

IntroductionRenovascular hypertension (RVH) remains underdiagnosed despite its significant cardiovascular and renal morbidity.AimThis survey investigated screening and management practices for RVH among hypertensive patients in Italian hypertension centres in a real-life setting. Secondary, we analysed the current spread of renal denervation (RDN) and the criteria used for its eligibility.MethodsA 12 item-questionnaire was sent to hypertension centres belonging to the European Society of Hypertension and to the Italian Society of Hypertension (SIIA) in Italy. Data concerning the screening and management of RVH and of RDN were analysed according to the type of centre (excellence vs non-excellence centres), geographical area and medical specialty.ResultsEighty-two centres participated to the survey. The number of patients diagnosed in each centre with RVH and fibromuscular dysplasia during the last five years was 3 [1;6] and 1 [0;2], respectively. Despite higher rates of RVH diagnosis in excellence centres (p = 0.017), overall numbers remained unacceptably low, when compared to expected prevalence estimates. Screening rates were inadequate, particularly among young hypertensive patients, with only 28% of the centres screening for RVH in such population. Renal duplex ultrasound was underused, with computed tomographic angiography or magnetic resonance angiography reserved for confirming a RVH diagnosis (76.8%) rather than for screening (1.9–32.7%, according to patients’ characteristics). Scepticism and logistical challenges limited RDN widespread adoption.ConclusionsThese findings underscore the need for improving RVH screening strategies and for a wider use of related diagnostic tools. Enhanced awareness and adherence to guidelines are crucial to identifying renovascular hypertension and mitigating associated cardiovascular and renal risks.