Lysosomal sugar transport: facilitated or free diffusion?

Bird et al. in a recent communication showed the results of experiments which they claim were a test of Hales's hypothesis that sugars enter rat liver lysosomes by a facilitated diffusion system. They explain results on the basis of uptake mediated by simple diffusion. In contrast, the authors...

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Bibliographic Details
Published in:Biochemical journal 1988-06, Vol.252 (2), p.621-623
Main Authors: Maguire, G A, Kay, J D, Hales, C N
Format: Article
Language:English
Subjects:
Biological Transport, Active
Diffusion
Glucose - pharmacokinetics
Letter
liver
lysosomes
Lysosomes - metabolism
Ribose - pharmacokinetics
sugars
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Summary:Bird et al. in a recent communication showed the results of experiments which they claim were a test of Hales's hypothesis that sugars enter rat liver lysosomes by a facilitated diffusion system. They explain results on the basis of uptake mediated by simple diffusion. In contrast, the authors explanation is based upon the properties of a carrier-mediated process.
ISSN:0264-6021
1470-8728
DOI:10.1042/bj2520621