YTHDF3 gene polymorphisms increase Wilms tumor risk in Chinese girls

Wilms tumor is a prevalent pediatric tumor influenced by various genetic factors. m A modification is a common nucleotide modification that plays a role in a variety of cancers. As a "reader", YTHDF3 is essential for recognizing m A modifications. However, the association between gene poly...

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Bibliographic Details
Published in:Journal of Cancer 2024-01, Vol.15 (18), p.6103-6109
Main Authors: Deng, Changmi, Han, Yufeng, Zhou, Haixia, Zhang, Jiao, Cheng, Jiwen, Li, Suhong, Ruan, Jichen, Liu, Guochang, He, Jing, Hua, Rui-Xi, Fu, Wen
Format: Article
Language:English
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Summary:Wilms tumor is a prevalent pediatric tumor influenced by various genetic factors. m A modification is a common nucleotide modification that plays a role in a variety of cancers. As a "reader", YTHDF3 is essential for recognizing m A modifications. However, the association between gene polymorphisms and Wilms tumor susceptibility has not been previously reported. A five-center case‒control study including 414 patients and 1199 controls was conducted to explore the relationship between gene polymorphisms and Wilms tumor susceptibility. The samples were genotyped via TaqMan real-time quantitative polymerase chain reaction. Odds ratios (ORs) and 95% confidence intervals (CIs) were utilized as indicators to assess their correlation. The rs2241753 AA genotype was significantly associated with an increased risk of Wilms tumor in females (adjusted OR=1.74, 95% CI=1.05-2.88, =0.033). The risk of Wilms tumor was also notably elevated in female children with 1-3 risk genotypes (adjusted OR=1.47, 95% CI=1.04-2.07, =0.028). The rs2241753 AA genotype and the presence of 1-3 risk genotypes were significantly associated with increased Wilms tumor risk in female children.
ISSN:1837-9664
1837-9664
DOI:10.7150/jca.99928