Overcoming barriers to single-cell RNA sequencing adoption in low- and middle-income countries

The advent of single-cell resolution sequencing and spatial transcriptomics has enabled the delivery of cellular and molecular atlases of tissues and organs, providing new insights into tissue health and disease. However, if the full potential of these technologies is to be equitably realised, ances...

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Bibliographic Details
Published in:European journal of human genetics : EJHG 2024-10, Vol.32 (10), p.1206-1213
Main Authors: Boakye Serebour, Tracy, Cribbs, Adam P., Baldwin, Mathew J., Masimirembwa, Collen, Chikwambi, Zedias, Kerasidou, Angeliki, Snelling, Sarah J. B.
Format: Article
Language:English
Subjects:
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Bioinformatics
Biomedical and Life Sciences
Biomedicine
Collaboration
Cytogenetics
Developing Countries
Gene Expression
Genetic testing
Genomes
Genomics
Human body
Human Genetics
Humans
Inclusion
Low income groups
Rare diseases
Review
Review Article
Sequence Analysis, RNA - methods
Single-Cell Analysis - methods
Transcriptomics
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Summary:The advent of single-cell resolution sequencing and spatial transcriptomics has enabled the delivery of cellular and molecular atlases of tissues and organs, providing new insights into tissue health and disease. However, if the full potential of these technologies is to be equitably realised, ancestrally inclusivity is paramount. Such a goal requires greater inclusion of both researchers and donors in low- and middle-income countries (LMICs). In this perspective, we describe the current landscape of ancestral inclusivity in genomic and single-cell transcriptomic studies. We discuss the collaborative efforts needed to scale the barriers to establishing, expanding, and adopting single-cell sequencing research in LMICs and to enable globally impactful outcomes of these technologies.
ISSN:1018-4813
1476-5438
1476-5438
DOI:10.1038/s41431-024-01564-4