Idiopathic Mixed Cryoglobulinemia: A Diagnostic Challenge

Mixed cryoglobulinemia (MC) is commonly associated with chronic hepatitis C infection. Symptoms usually present as a clinical triad of purpuric rash, arthralgia, and generalized weakness. There have been several case reports establishing the relationship between hepatitis C and MC. Here, we report a...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2024-09, Vol.16 (9), p.e70069
Main Authors: Rathi, Hinal, Patra, Tumpa, Poojary, Indira, Pathak, Prutha R, Haley, Heather
Format: Article
Language:English
Subjects:
Genetics
Internal Medicine
Nephrology
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Summary:Mixed cryoglobulinemia (MC) is commonly associated with chronic hepatitis C infection. Symptoms usually present as a clinical triad of purpuric rash, arthralgia, and generalized weakness. There have been several case reports establishing the relationship between hepatitis C and MC. Here, we report a case of a 22-year-old female presenting with bilateral lower extremity and facial swelling with no history of hepatitis C developing idiopathic mixed cryoglobulinemia. She was treated with intravenous steroids, rituximab, and plasmapheresis, resulting in improvement with outpatient nephrology and oncology follow-ups.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.70069