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Brain-Derived Neurotrophic Factor rs6265 polymorphism is associated with severe cancer-related fatigue and neuropathic pain in female cancer survivors
Purpose This study examined the relationships between a single-nucleotide polymorphism (SNP) of brain-derived neurotrophic factor ( BDNF ) rs6265 and psychoneurological (PN) symptoms in female cancer survivors. Methods This secondary analysis examined 393 study participants. In addition to demograph...
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| Published in: | Journal of cancer survivorship 2024-12, Vol.18 (6), p.1851-1860 |
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| container_end_page | 1860 |
| container_issue | 6 |
| container_start_page | 1851 |
| container_title | Journal of cancer survivorship |
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| creator | Goto, Taichi Von Ah, Diane Li, Xiaobai Xiang, Lichen Kwiat, Catherine Nguyen, Christopher Hsiao, Chao-Pin Saligan, Leorey N. |
| description | Purpose
This study examined the relationships between a single-nucleotide polymorphism (SNP) of brain-derived neurotrophic factor (
BDNF
) rs6265 and psychoneurological (PN) symptoms in female cancer survivors.
Methods
This secondary analysis examined 393 study participants. In addition to demographic variables, self-reported PN symptom scores (anxiety, bodily pain, depression, fatigue, neuropathic pain, and sleep disturbance) were collected using the Patient-Reported Outcomes Measurement Information System and 36-Item Short-Form Health Survey. Buccal swab samples were collected to obtain genotypes for
BDNF
rs6265 (Val/Val, Val/Met, or Met/Met). The PN symptom scores were compared across genotypes, and the relationships were examined using a regression model. We also explored correlations between different symptoms within each genotype.
Results
Participants with the Met/Met genotype reported significantly worse cancer-related fatigue and neuropathic pain, which was confirmed by rank-based regression analysis. In addition, cancer-related fatigue was correlated with other PN symptoms, particularly depression. These correlations were stronger in study participants with the Met/Met genotype than those with other genotypes.
Conclusion
Our study suggests that female cancer survivors with the Met/Met genotype of
BDNF
rs6265 are likely to experience worse cancer-related fatigue and neuropathic pain and that cancer-related fatigue is a good predictor of co-occurring PN symptoms in this population.
Implications for Cancer Survivors
Our findings advance the scientific community's understanding of cancer-related PN symptoms experienced by female cancer survivors, especially the unique role of
BDNF
rs6265 polymorphism in these symptoms. Our findings offer valuable insights for clinical practice that the symptom experience among female cancer survivors may vary based on BDNF genotypes. |
| doi_str_mv | 10.1007/s11764-023-01426-w |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11502548</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2839247036</sourcerecordid><originalsourceid>FETCH-LOGICAL-c475t-f5cfafac4f8da41249eb311bfa00827d2a7661ea3a504745b1943ea4367806f33</originalsourceid><addsrcrecordid>eNp9kc1u1DAUhSMEoqXwAiyQJTZsAv6LnawQLRSQKtjA2rrj3My4SuJwncyoL8Lz4um0w88CyZItnXO-66tTFM8Ffy04t2-SENbokktVcqGlKXcPilPRKFlKaezD47tqToonKV1zXslGyMfFibLayIbr0-LnOUEYy_dIYYst-4ILxZnitAmeXYKfIzFKRpqKTbG_GSJlJQ0sJAYpRR9gzqldmDcs4RYJmYfRI5WE_a3UwRzWCzIYWzbu4RPMe_aUp7J8Ohygv0-xtNA2bCOlp8WjDvqEz-7us-L75YdvF5_Kq68fP1-8uyq9ttVcdpXvoAOvu7oFLaRucKWEWHXAeS1tK8EaIxAUVFxbXa1EoxWCVsbW3HRKnRVvD9xpWQ3Yehxngt5NFAagGxchuL-VMWzcOm6dEBWXla4z4dUdgeKPBdPshpA89j2MGJfkZK0aqS1XJltf_mO9jguNeT-nhOSS19bI7JIHl6eYEmF3_I3gbt-7O_Tucu_utne3y6EXf-5xjNwXnQ3qYEhZGtdIv2f_B_sLeGS8sA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3120208762</pqid></control><display><type>article</type><title>Brain-Derived Neurotrophic Factor rs6265 polymorphism is associated with severe cancer-related fatigue and neuropathic pain in female cancer survivors</title><source>Springer Link</source><creator>Goto, Taichi ; Von Ah, Diane ; Li, Xiaobai ; Xiang, Lichen ; Kwiat, Catherine ; Nguyen, Christopher ; Hsiao, Chao-Pin ; Saligan, Leorey N.</creator><creatorcontrib>Goto, Taichi ; Von Ah, Diane ; Li, Xiaobai ; Xiang, Lichen ; Kwiat, Catherine ; Nguyen, Christopher ; Hsiao, Chao-Pin ; Saligan, Leorey N.</creatorcontrib><description>Purpose
This study examined the relationships between a single-nucleotide polymorphism (SNP) of brain-derived neurotrophic factor (
BDNF
) rs6265 and psychoneurological (PN) symptoms in female cancer survivors.
Methods
This secondary analysis examined 393 study participants. In addition to demographic variables, self-reported PN symptom scores (anxiety, bodily pain, depression, fatigue, neuropathic pain, and sleep disturbance) were collected using the Patient-Reported Outcomes Measurement Information System and 36-Item Short-Form Health Survey. Buccal swab samples were collected to obtain genotypes for
BDNF
rs6265 (Val/Val, Val/Met, or Met/Met). The PN symptom scores were compared across genotypes, and the relationships were examined using a regression model. We also explored correlations between different symptoms within each genotype.
Results
Participants with the Met/Met genotype reported significantly worse cancer-related fatigue and neuropathic pain, which was confirmed by rank-based regression analysis. In addition, cancer-related fatigue was correlated with other PN symptoms, particularly depression. These correlations were stronger in study participants with the Met/Met genotype than those with other genotypes.
Conclusion
Our study suggests that female cancer survivors with the Met/Met genotype of
BDNF
rs6265 are likely to experience worse cancer-related fatigue and neuropathic pain and that cancer-related fatigue is a good predictor of co-occurring PN symptoms in this population.
Implications for Cancer Survivors
Our findings advance the scientific community's understanding of cancer-related PN symptoms experienced by female cancer survivors, especially the unique role of
BDNF
rs6265 polymorphism in these symptoms. Our findings offer valuable insights for clinical practice that the symptom experience among female cancer survivors may vary based on BDNF genotypes.</description><identifier>ISSN: 1932-2259</identifier><identifier>ISSN: 1932-2267</identifier><identifier>EISSN: 1932-2267</identifier><identifier>DOI: 10.1007/s11764-023-01426-w</identifier><identifier>PMID: 37462904</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adult ; Aged ; Brain-derived neurotrophic factor ; Brain-Derived Neurotrophic Factor - genetics ; Cancer ; Cancer Survivors - psychology ; Fatigue ; Fatigue - etiology ; Fatigue - genetics ; Female ; Females ; Gene polymorphism ; Genotype ; Genotype & phenotype ; Health Informatics ; Health Promotion and Disease Prevention ; Humans ; Medicine ; Medicine & Public Health ; Mental depression ; Middle Aged ; Neoplasms - complications ; Neoplasms - genetics ; Neuralgia ; Neuralgia - etiology ; Neuralgia - genetics ; Oncology ; Original Paper ; Pain ; Polymorphism ; Polymorphism, Single Nucleotide ; Primary Care Medicine ; Public Health ; Quality of Life Research ; Single-nucleotide polymorphism</subject><ispartof>Journal of cancer survivorship, 2024-12, Vol.18 (6), p.1851-1860</ispartof><rights>This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023</rights><rights>2023. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.</rights><rights>This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-f5cfafac4f8da41249eb311bfa00827d2a7661ea3a504745b1943ea4367806f33</citedby><cites>FETCH-LOGICAL-c475t-f5cfafac4f8da41249eb311bfa00827d2a7661ea3a504745b1943ea4367806f33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37462904$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Goto, Taichi</creatorcontrib><creatorcontrib>Von Ah, Diane</creatorcontrib><creatorcontrib>Li, Xiaobai</creatorcontrib><creatorcontrib>Xiang, Lichen</creatorcontrib><creatorcontrib>Kwiat, Catherine</creatorcontrib><creatorcontrib>Nguyen, Christopher</creatorcontrib><creatorcontrib>Hsiao, Chao-Pin</creatorcontrib><creatorcontrib>Saligan, Leorey N.</creatorcontrib><title>Brain-Derived Neurotrophic Factor rs6265 polymorphism is associated with severe cancer-related fatigue and neuropathic pain in female cancer survivors</title><title>Journal of cancer survivorship</title><addtitle>J Cancer Surviv</addtitle><addtitle>J Cancer Surviv</addtitle><description>Purpose
This study examined the relationships between a single-nucleotide polymorphism (SNP) of brain-derived neurotrophic factor (
BDNF
) rs6265 and psychoneurological (PN) symptoms in female cancer survivors.
Methods
This secondary analysis examined 393 study participants. In addition to demographic variables, self-reported PN symptom scores (anxiety, bodily pain, depression, fatigue, neuropathic pain, and sleep disturbance) were collected using the Patient-Reported Outcomes Measurement Information System and 36-Item Short-Form Health Survey. Buccal swab samples were collected to obtain genotypes for
BDNF
rs6265 (Val/Val, Val/Met, or Met/Met). The PN symptom scores were compared across genotypes, and the relationships were examined using a regression model. We also explored correlations between different symptoms within each genotype.
Results
Participants with the Met/Met genotype reported significantly worse cancer-related fatigue and neuropathic pain, which was confirmed by rank-based regression analysis. In addition, cancer-related fatigue was correlated with other PN symptoms, particularly depression. These correlations were stronger in study participants with the Met/Met genotype than those with other genotypes.
Conclusion
Our study suggests that female cancer survivors with the Met/Met genotype of
BDNF
rs6265 are likely to experience worse cancer-related fatigue and neuropathic pain and that cancer-related fatigue is a good predictor of co-occurring PN symptoms in this population.
Implications for Cancer Survivors
Our findings advance the scientific community's understanding of cancer-related PN symptoms experienced by female cancer survivors, especially the unique role of
BDNF
rs6265 polymorphism in these symptoms. Our findings offer valuable insights for clinical practice that the symptom experience among female cancer survivors may vary based on BDNF genotypes.</description><subject>Adult</subject><subject>Aged</subject><subject>Brain-derived neurotrophic factor</subject><subject>Brain-Derived Neurotrophic Factor - genetics</subject><subject>Cancer</subject><subject>Cancer Survivors - psychology</subject><subject>Fatigue</subject><subject>Fatigue - etiology</subject><subject>Fatigue - genetics</subject><subject>Female</subject><subject>Females</subject><subject>Gene polymorphism</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Health Informatics</subject><subject>Health Promotion and Disease Prevention</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mental depression</subject><subject>Middle Aged</subject><subject>Neoplasms - complications</subject><subject>Neoplasms - genetics</subject><subject>Neuralgia</subject><subject>Neuralgia - etiology</subject><subject>Neuralgia - genetics</subject><subject>Oncology</subject><subject>Original Paper</subject><subject>Pain</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Primary Care Medicine</subject><subject>Public Health</subject><subject>Quality of Life Research</subject><subject>Single-nucleotide polymorphism</subject><issn>1932-2259</issn><issn>1932-2267</issn><issn>1932-2267</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kc1u1DAUhSMEoqXwAiyQJTZsAv6LnawQLRSQKtjA2rrj3My4SuJwncyoL8Lz4um0w88CyZItnXO-66tTFM8Ffy04t2-SENbokktVcqGlKXcPilPRKFlKaezD47tqToonKV1zXslGyMfFibLayIbr0-LnOUEYy_dIYYst-4ILxZnitAmeXYKfIzFKRpqKTbG_GSJlJQ0sJAYpRR9gzqldmDcs4RYJmYfRI5WE_a3UwRzWCzIYWzbu4RPMe_aUp7J8Ohygv0-xtNA2bCOlp8WjDvqEz-7us-L75YdvF5_Kq68fP1-8uyq9ttVcdpXvoAOvu7oFLaRucKWEWHXAeS1tK8EaIxAUVFxbXa1EoxWCVsbW3HRKnRVvD9xpWQ3Yehxngt5NFAagGxchuL-VMWzcOm6dEBWXla4z4dUdgeKPBdPshpA89j2MGJfkZK0aqS1XJltf_mO9jguNeT-nhOSS19bI7JIHl6eYEmF3_I3gbt-7O_Tucu_utne3y6EXf-5xjNwXnQ3qYEhZGtdIv2f_B_sLeGS8sA</recordid><startdate>20241201</startdate><enddate>20241201</enddate><creator>Goto, Taichi</creator><creator>Von Ah, Diane</creator><creator>Li, Xiaobai</creator><creator>Xiang, Lichen</creator><creator>Kwiat, Catherine</creator><creator>Nguyen, Christopher</creator><creator>Hsiao, Chao-Pin</creator><creator>Saligan, Leorey N.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20241201</creationdate><title>Brain-Derived Neurotrophic Factor rs6265 polymorphism is associated with severe cancer-related fatigue and neuropathic pain in female cancer survivors</title><author>Goto, Taichi ; Von Ah, Diane ; Li, Xiaobai ; Xiang, Lichen ; Kwiat, Catherine ; Nguyen, Christopher ; Hsiao, Chao-Pin ; Saligan, Leorey N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-f5cfafac4f8da41249eb311bfa00827d2a7661ea3a504745b1943ea4367806f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Brain-derived neurotrophic factor</topic><topic>Brain-Derived Neurotrophic Factor - genetics</topic><topic>Cancer</topic><topic>Cancer Survivors - psychology</topic><topic>Fatigue</topic><topic>Fatigue - etiology</topic><topic>Fatigue - genetics</topic><topic>Female</topic><topic>Females</topic><topic>Gene polymorphism</topic><topic>Genotype</topic><topic>Genotype & phenotype</topic><topic>Health Informatics</topic><topic>Health Promotion and Disease Prevention</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mental depression</topic><topic>Middle Aged</topic><topic>Neoplasms - complications</topic><topic>Neoplasms - genetics</topic><topic>Neuralgia</topic><topic>Neuralgia - etiology</topic><topic>Neuralgia - genetics</topic><topic>Oncology</topic><topic>Original Paper</topic><topic>Pain</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Primary Care Medicine</topic><topic>Public Health</topic><topic>Quality of Life Research</topic><topic>Single-nucleotide polymorphism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goto, Taichi</creatorcontrib><creatorcontrib>Von Ah, Diane</creatorcontrib><creatorcontrib>Li, Xiaobai</creatorcontrib><creatorcontrib>Xiang, Lichen</creatorcontrib><creatorcontrib>Kwiat, Catherine</creatorcontrib><creatorcontrib>Nguyen, Christopher</creatorcontrib><creatorcontrib>Hsiao, Chao-Pin</creatorcontrib><creatorcontrib>Saligan, Leorey N.</creatorcontrib><collection>Springer_OA刊</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of cancer survivorship</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goto, Taichi</au><au>Von Ah, Diane</au><au>Li, Xiaobai</au><au>Xiang, Lichen</au><au>Kwiat, Catherine</au><au>Nguyen, Christopher</au><au>Hsiao, Chao-Pin</au><au>Saligan, Leorey N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Brain-Derived Neurotrophic Factor rs6265 polymorphism is associated with severe cancer-related fatigue and neuropathic pain in female cancer survivors</atitle><jtitle>Journal of cancer survivorship</jtitle><stitle>J Cancer Surviv</stitle><addtitle>J Cancer Surviv</addtitle><date>2024-12-01</date><risdate>2024</risdate><volume>18</volume><issue>6</issue><spage>1851</spage><epage>1860</epage><pages>1851-1860</pages><issn>1932-2259</issn><issn>1932-2267</issn><eissn>1932-2267</eissn><abstract>Purpose
This study examined the relationships between a single-nucleotide polymorphism (SNP) of brain-derived neurotrophic factor (
BDNF
) rs6265 and psychoneurological (PN) symptoms in female cancer survivors.
Methods
This secondary analysis examined 393 study participants. In addition to demographic variables, self-reported PN symptom scores (anxiety, bodily pain, depression, fatigue, neuropathic pain, and sleep disturbance) were collected using the Patient-Reported Outcomes Measurement Information System and 36-Item Short-Form Health Survey. Buccal swab samples were collected to obtain genotypes for
BDNF
rs6265 (Val/Val, Val/Met, or Met/Met). The PN symptom scores were compared across genotypes, and the relationships were examined using a regression model. We also explored correlations between different symptoms within each genotype.
Results
Participants with the Met/Met genotype reported significantly worse cancer-related fatigue and neuropathic pain, which was confirmed by rank-based regression analysis. In addition, cancer-related fatigue was correlated with other PN symptoms, particularly depression. These correlations were stronger in study participants with the Met/Met genotype than those with other genotypes.
Conclusion
Our study suggests that female cancer survivors with the Met/Met genotype of
BDNF
rs6265 are likely to experience worse cancer-related fatigue and neuropathic pain and that cancer-related fatigue is a good predictor of co-occurring PN symptoms in this population.
Implications for Cancer Survivors
Our findings advance the scientific community's understanding of cancer-related PN symptoms experienced by female cancer survivors, especially the unique role of
BDNF
rs6265 polymorphism in these symptoms. Our findings offer valuable insights for clinical practice that the symptom experience among female cancer survivors may vary based on BDNF genotypes.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>37462904</pmid><doi>10.1007/s11764-023-01426-w</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 1932-2259 1932-2267 1932-2267 |
| language | eng |
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| subjects | Adult Aged Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - genetics Cancer Cancer Survivors - psychology Fatigue Fatigue - etiology Fatigue - genetics Female Females Gene polymorphism Genotype Genotype & phenotype Health Informatics Health Promotion and Disease Prevention Humans Medicine Medicine & Public Health Mental depression Middle Aged Neoplasms - complications Neoplasms - genetics Neuralgia Neuralgia - etiology Neuralgia - genetics Oncology Original Paper Pain Polymorphism Polymorphism, Single Nucleotide Primary Care Medicine Public Health Quality of Life Research Single-nucleotide polymorphism |
| title | Brain-Derived Neurotrophic Factor rs6265 polymorphism is associated with severe cancer-related fatigue and neuropathic pain in female cancer survivors |
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