Behavior of jittering potential before and after impulse blockings: a preliminary study in myasthenia gravis

Neuromuscular junction disorders lead to secession of bioelectrical activity transmission between motor nerve endings and muscle fibers. In diseases that are severe enough, impulse blockings are observed. This study aims to reveal the behavior of neuromuscular junction before and after impulse block...

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Bibliographic Details
Published in:Biomedical engineering letters 2024-11, Vol.14 (6), p.1303-1318
Main Author: Artuğ, N. Tuğrul
Format: Article
Language:English
Subjects:
Algorithms
Bioelectricity
Biological and Medical Physics
Biomedical Engineering and Bioengineering
Biomedicine
Biophysics
Engineering
Medical and Radiation Physics
Muscle contraction
Muscles
Myasthenia gravis
Nerve endings
Neuromuscular junctions
Original
Original Article
Parameters
Vibration
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Summary:Neuromuscular junction disorders lead to secession of bioelectrical activity transmission between motor nerve endings and muscle fibers. In diseases that are severe enough, impulse blockings are observed. This study aims to reveal the behavior of neuromuscular junction before and after impulse blockings. Fourteen recordings harboring impulse blockings from nine myasthenia gravis (MG) patients were included. Recordings were made from frontalis muscle by using concentric needle electrode during voluntary contraction. One hundred traces were acquired in each session. In addition to well-known jitter parameters, new parameters were calculated such as number of consecutive impulse blocking groups, number of impulse blockings in each group, ratio of maximum number of consecutive impulse blockings to all number of blockings. Graphics were composed to show location change behavior of jittering potential in all traces. For jittering potential, before or after a single impulse blocking the amount of getting further away from trigger peak was greater than getting closer to trigger peak. However, after consecutive impulse blockings the amount of getting closer to trigger peak was greater than the amount of getting further away. The behavior of neuromuscular junction before and after impulse blockings was demonstrated in MG patients. Moreover, new features were extracted for jitter studies. Building models for different diseases according to their impulse blockings may be possible with the developed algorithm. Graphical abstract
ISSN:2093-9868
2093-985X
2093-985X
DOI:10.1007/s13534-024-00401-3