Achieved oxygen saturations and risk for bronchopulmonary dysplasia with pulmonary hypertension in preterm infants

ObjectiveCharacterisation of oxygen saturation (SpO2)-related predictors that correspond with both bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH) development and survival status in infants with BPD-PH may improve patient outcomes. This investigation assessed whether (1) infant...

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Bibliographic Details
Published in:Archives of disease in childhood 2024-11, Vol.109 (11), p.941-947
Main Authors: Gentle, Samuel J, Singh, Avinash, Travers, Colm P, Nakhmani, Arie, Carlo, Waldemar A, Ambalavanan, Namasivayam
Format: Article
Language:English
Subjects:
Body Weight
Continuous positive airway pressure
Dysplasia
Evidence
Gestational age
Grade 1
Grade 2
Hypertension
Infants
Intensive Care Units, Neonatal
Lung diseases
Meta Analysis
Neonates
Neonatology
Newborn babies
Nonparametric Statistics
Original Research
Oxygen
Oxygen saturation
Population Distribution
Postpartum period
Pregnancy
Premature babies
Premature Infants
Pulmonary hypertension
Pulse oximetry
Respiratory Medicine
Saturation index
Statistical Analysis
Survival
Ultrasonic imaging
Young Children
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Summary:ObjectiveCharacterisation of oxygen saturation (SpO2)-related predictors that correspond with both bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH) development and survival status in infants with BPD-PH may improve patient outcomes. This investigation assessed whether (1) infants with BPD-PH compared with infants with BPD alone, and (2) BPD-PH non-survivors compared with BPD-PH survivors would (a) achieve lower SpO2 distributions, (b) have a higher fraction of inspired oxygen (FiO2) exposure and (c) have a higher oxygen saturation index (OSI).DesignCase–control study between infants with BPD-PH (cases) and BPD alone (controls) and by survival status within cases.SettingSingle-centre study in the USA.PatientsInfants born at
ISSN:0003-9888
1468-2044
1468-2044
DOI:10.1136/archdischild-2024-327014