Aggregation-Induced Emission Luminogen: Role in Biopsy for Precision Medicine

Biopsy, including tissue and liquid biopsy, offers comprehensive and real-time physiological and pathological information for disease detection, diagnosis, and monitoring. Fluorescent probes are frequently selected to obtain adequate information on pathological processes in a rapid and minimally inv...

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Bibliographic Details
Published in:Chemical reviews 2024-10, Vol.124 (20), p.11242-11347
Main Authors: Duo, Yanhong, Han, Lei, Yang, Yaoqiang, Wang, Zhifeng, Wang, Lirong, Chen, Jingyi, Xiang, Zhongyuan, Yoon, Juyoung, Luo, Guanghong, Tang, Ben Zhong
Format: Article
Language:English
Subjects:
Biopsy
blood sampling
Disease detection
Emission
Emissions
fluorescence
Fluorescent indicators
liquids
Precision medicine
Probes
Real time
Review
saliva
Signal to noise ratio
urine
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Summary:Biopsy, including tissue and liquid biopsy, offers comprehensive and real-time physiological and pathological information for disease detection, diagnosis, and monitoring. Fluorescent probes are frequently selected to obtain adequate information on pathological processes in a rapid and minimally invasive manner based on their advantages for biopsy. However, conventional fluorescent probes have been found to show aggregation-caused quenching (ACQ) properties, impeding greater progresses in this area. Since the discovery of aggregation-induced emission luminogen (AIEgen) have promoted rapid advancements in molecular bionanomaterials owing to their unique properties, including high quantum yield (QY) and signal-to-noise ratio (SNR), etc. This review seeks to present the latest advances in AIEgen-based biofluorescent probes for biopsy in real or artificial samples, and also the key properties of these AIE probes. This review is divided into: (i) tissue biopsy based on smart AIEgens, (ii) blood sample biopsy based on smart AIEgens, (iii) urine sample biopsy based on smart AIEgens, (iv) saliva sample biopsy based on smart AIEgens, (v) biopsy of other liquid samples based on smart AIEgens, and (vi) perspectives and conclusion. This review could provide additional guidance to motivate interest and bolster more innovative ideas for further exploring the applications of various smart AIEgens in precision medicine.
ISSN:0009-2665
1520-6890
1520-6890
DOI:10.1021/acs.chemrev.4c00244