Photodynamic Therapy: Past, Current, and Future

• Published in: International journal of molecular sciences 2024-10, Vol.25 (20), p.11325
• Main Authors: Aebisher, David, Czech, Sara, Dynarowicz, Klaudia, Misiołek, Maciej, Komosińska-Vassev, Katarzyna, Kawczyk-Krupka, Aleksandra, Bartusik-Aebisher, Dorota
• Format: Article
• Language: English
• Subjects: Animals; Cancer; Cancer therapies; Clinical trials; Evolution; Health aspects; Humans; Light; Light therapy; Medical research; Neoplasms - drug therapy; Neoplasms - therapy; Photochemotherapy; Photochemotherapy - methods; Photodynamic therapy; Photosensitizing Agents - therapeutic use; Psoriasis; Reactive oxygen species; Reactive Oxygen Species - metabolism; Review; Skin; Sun; Technological change; Tuberculosis; Tumors; Ultraviolet radiation; Verteporfin
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms252011325

The Greek roots of the word "photodynamic" are as follows: "phos" (φω~ς) means "light" and "dynamis" (δύναμις) means "force" or "power". Photodynamic therapy (PDT) is an innovative treatment method based on the ability of photosensitizers to produce reactive oxygen species after the exposure to light that corresponds to an absorbance wavelength of the photosensitizer, either in the visible or near-infrared range. This process results in damage to pathological cancer cells, while minimizing the impact on healthy tissues. PDT is a promising direction in the treatment of many diseases, with particular emphasis on the fight against cancer and other diseases associated with excessive cell growth. The power of light contributed to the creation of phototherapy, whose history dates back to ancient times. It was then noticed that some substances exposed to the sun have a negative effect on the body, while others have a therapeutic effect. This work provides a detailed review of photodynamic therapy, from its origins to the present day. It is surprising how a seemingly simple beam of light can have such a powerful healing effect, which is used not only in dermatology, but also in oncology, surgery, microbiology, virology, and even dentistry. However, despite promising results, photodynamic therapy still faces many challenges. Moreover, photodynamic therapy requires further research and improvement.