Antiphospholipid Antibodies as Key Players in Systemic Lupus Erythematosus: The Relationship with Cytokines and Immune Dysregulation

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by an overproduction of cytokines, such as interleukins and interferons, contributing to systemic inflammation and tissue damage. Antiphospholipid syndrome is a thrombo-inflammatory autoimmune disease affecting a third...

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Bibliographic Details
Published in:International journal of molecular sciences 2024-10, Vol.25 (20), p.11281
Main Authors: Richter, Patricia, Badescu, Minerva Codruta, Rezus, Ciprian, Ouatu, Anca, Dima, Nicoleta, Popescu, Diana, Burlui, Alexandra Maria, Bratoiu, Ioana, Mihai, Ioana Ruxandra, Rezus, Elena
Format: Article
Language:English
Subjects:
Analysis
Animals
Antibodies
Antibodies, Antiphospholipid - immunology
Anticoagulants
Antiphospholipid antibodies
Antiphospholipid Syndrome - immunology
Autoimmune diseases
Blood clot
Cytokines
Cytokines - immunology
Cytokines - metabolism
Development and progression
Disease
Endothelium
Genetic markers
Genotype & phenotype
Glycoproteins
Heparan sulfate
Humans
Inflammation
Inflammation - immunology
Lupus
Lupus Erythematosus, Systemic - immunology
MicroRNAs
Pathogenesis
Proteins
Review
Systemic lupus erythematosus
Thrombosis
Thrombosis - immunology
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Summary:Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by an overproduction of cytokines, such as interleukins and interferons, contributing to systemic inflammation and tissue damage. Antiphospholipid syndrome is a thrombo-inflammatory autoimmune disease affecting a third of SLE patients. We performed an in-depth analysis of the available literature, and we highlighted the complex interplay between immunity, inflammation, and thrombosis, the three major pathogenic pathways that are trapped in a mutually reinforcing destructive loop.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms252011281