Frontoparietal network and neuropsychological measures in typically developing children

• Published in: Neuropsychologia 2021-08, Vol.159, p.107914-107914, Article 107914
• Main Authors: Solis, Isabel, Janowich, Jacki, Candelaria-Cook, Felicha, Collishaw, William, Wang, Yu-Ping, Wilson, Tony W., Calhoun, Vince D., Ciesielski, Kristina R.T., Stephen, Julia M.
• Format: Article
• Language: English
• Subjects: Adolescent; Attention; Brain; Child; Child, Preschool; Eye; Frontal Lobe; Frontoparietal network; Humans; Magnetoencephalography; Neurodevelopment; Parietal Lobe - diagnostic imaging; Resting-state
• ISSN: 0028-3932; 1873-3514; 1873-3514
• DOI: 10.1016/j.neuropsychologia.2021.107914

Resting-state activity has been used to gain a broader understanding of typical and aberrant developmental changes. However, the developmental trajectory of resting-state activity in relation to cognitive performance has not been studied in detail. The present study assessed spectral characteristics of theta (5–8 Hz) and alpha (9–13 Hz) frequency bands during resting-state in a priori selected regions of the frontoparietal network (FPN). We also examined the relationship between resting-state activity and cognitive performance in typically developing children. We hypothesized that older children and children with high attentional scores would have higher parietal alpha activity and frontal theta activity while at rest compared to young children and those with lower attentional scores. MEG data were collected in 65 typically developing children, ages 9–14 years, as part of the Developmental Chronnecto-Genomics study. Resting-state data were collected during eyes open and eyes closed for 5 min. Participants completed the NIH Toolbox Flanker Inhibitory Control (FICA) and Attention Test and Dimensional Change Card Sort Test (DCCS) to assess top-down attentional control. Spectral power density was used to characterize the FPN. We found during eyes open and eyes closed, all participants had higher theta and alpha power in parietal regions relative to frontal regions. The group with high attentional scores had higher alpha power during resting-state eyes closed compared to those with low attentional scores. However, there were no significant differences between age groups, suggesting changes in the maturation of neural oscillations in theta and alpha are not evident among children in the 9-14-year age range. •Alpha power is associated with neuropsychological performance on attention tasks.•Theta and alpha power are greater in parietal regions relative to frontal regions.•Children with high resting alpha power also scored high in the attentional task.•Low variation in alpha reactivity across age and attentional ability.