Mangiferin: An effective agent against human malignancies

• Published in: Food science & nutrition 2024-10, Vol.12 (10), p.7137-7157
• Main Authors: Irshad, Nimra, Naeem, Hammad, Shahbaz, Muhammad, Imran, Muhammad, Mujtaba, Ahmed, Hussain, Muzzamal, Al Abdulmonem, Waleed, Alsagaby, Suliman A., Yehuala, Tadesse Fenta, Abdelgawad, Mohamed A., Ghoneim, Mohammed M., Mostafa, Ehab M., Selim, Samy, Al Jaouni, Soad K.
• Format: Article
• Language: English
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT protein; anticancer; Antioxidants; Apoptosis; bioactive compound; Bioavailability; Cancer; Cardiovascular disease; Cell adhesion molecules; Cell cycle; Chemokines; chemopreventive; chronic pancreatitis; Clinical trials; Diabetes; DIABLO protein; Drug dosages; Flavonoids; Fourier transforms; Free radicals; Gastric cancer; Growth factors; Health risks; Hepatitis; IAP protein; Iodides; Kinases; Leukemia; Liver cancer; Lung cancer; Malignancy; mangiferin; MAP kinase; Metastases; Oral administration; Ovarian cancer; Oxidative stress; Pancreatitis; Permeability; Pharmacokinetics; Pharmacology; Phosphors; Phytochemicals; Propidium iodide; Prostate cancer; Proteins; Review; Smad protein; Stat3 protein; therapeutic alternative; Transcription factors; Transforming growth factor-b
• ISSN: 2048-7177; 2048-7177
• DOI: 10.1002/fsn3.4434

Mangiferin is a bioactive substance present in high concentration in mangoes and also in some other fruits. Owing to its potential as a chemopreventive and chemotherapeutic agent against several types of cancer, this unique, significant, and well‐researched polyphenol has received a lot of attention recently. It possesses the ability to treat cancers, including rectal cancer, prostate cancer, ovarian cancer, leukemia, gastric cancer, liver cancer, chronic pancreatitis, and lung cancer. It can control/regulate multiple key signaling pathways, such as signal transducer and activator of transcription 3 (STAT3), second mitochondria‐derived activator of caspases/direct inhibitor of apoptosis (IAP)‐binding protein with low propidium iodide (pl) (Smac/DIABLO) nuclear factor kappa B (NF‐κB), phosphatidylinositol 3 kinase/protein 3 kinase (PI3K/Akt), transforming growth factor beta/suppressor of mothers against decapentaplegic (TGF‐β/SMAD), c‐jun N‐terminal kinase/p38 mitogen‐activated protein kinase (JNK/p38‐MAPK), and phosphor‐I kappa B kinase (p‐IκB), which are crucial to the development of cancers. By triggering apoptotic signals and halting the advancement of the cell cycle, it can also prevent some cancer cell types from proliferating and developing. It has been revealed that mangiferin targets a variety of adhesion molecules, cytokines, pro‐inflammatory transcription factors, kinases, chemokines, growth factors, and cell‐cycle proteins. By means of preventing the onset, advancement, and metastasis of cancer, these targets may mediate the chemopreventive and therapeutic effects of mangiferin. Mangiferin has confirmed potential benefits in lung, cervical, breast, brain, and prostate cancers as well as leukemia whether administered alone or in combination with recognized anticancer compounds. More clinical trials and research investigations are required to completely unleash the potential of mangiferin, which may lower the risk of cancer onset and act as a preventive and therapeutic alternative for a number of cancers. Mangiferin is a bioactive ingredient obtained from mango tree (Mangifera indica L.), a plant that has multiple uses in medicine. Mangiferin has confirmed potential benefits in lung, cervical, breast, brain, and prostate cancers as well as leukemia whether administered alone or in combination with recognized anticancer compounds. More clinical trials and research investigations are required to completely unleash the potential of mangiferin, which