GDP binding to brown-adipose-tissue mitochondria of mice treated chronically with corticosterone

Cytochrome oxidase activity and mitochondrial GDP binding were decreased in brown adipose tissue of mice treated chronically with corticosterone. These changes occurred both in corticosterone-treated mice fed ad libitum and in treated mice pair-fed to control animals. Although the dietary stimulatio...

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Bibliographic Details
Published in:Biochemical journal 1983-07, Vol.214 (1), p.265-268
Main Authors: Galpin, K S, Henderson, R G, James, W P, Trayhurn, P
Format: Article
Language:English
Subjects:
adipose tissue (brown)
Adipose Tissue, Brown - drug effects
Adipose Tissue, Brown - enzymology
Adipose Tissue, Brown - metabolism
Animals
Cold Temperature
corticosterone
Corticosterone - pharmacology
cytochrome oxidase
Electron Transport Complex IV - metabolism
Food
GDP
Guanine Nucleotides - metabolism
Guanosine Diphosphate - metabolism
Male
Mice
Mice, Inbred C57BL
Mitochondria - drug effects
Mitochondria - metabolism
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Description
Summary:Cytochrome oxidase activity and mitochondrial GDP binding were decreased in brown adipose tissue of mice treated chronically with corticosterone. These changes occurred both in corticosterone-treated mice fed ad libitum and in treated mice pair-fed to control animals. Although the dietary stimulation of brown-adipose-tissue thermogenesis was suppressed by corticosterone, the acute response to cold was not affected.
ISSN:0264-6021
1470-8728
DOI:10.1042/bj2140265