Efficacy of neutral electrolyzed water vs. common topical antiseptics in the healing of full‑thickness burn: Preclinical trial in a mouse model

Burn injuries impose challenges such as infection risk, pain management, fluid loss, electrolyte imbalance and psychological and emotional impact, on healthcare professionals, requiring effective treatments to enhance wound healing. The present study evaluated the efficacy superoxidized electrolyzed...

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Published in:Biomedical reports 2024-12, Vol.21 (6), p.189, Article 189
Main Authors: Delgado-Enciso, Ivan, Aurelien-Cabezas, Nomely S, Meza-Robles, Carmen, Walle-Guillen, Mireya, Hernandez-Fuentes, Gustavo A, Cabrera-Licona, Ariana, Hernandez-Rangel, Alejandra E, Delgado-Machuca, Marina, Rodriguez-Hernandez, Alejandrina, Beas-Guzman, Oscar F, Cardenas-Aguilar, Citlaly B, Rodriguez-Sanchez, Iram P, Martinez-Fierro, Margarita L, Chaviano-Conesa, Daniel, Paz-Michel, Brenda A
Format: Article
Language:English
Subjects:
Angiogenesis
Antibacterial agents
Antimicrobial agents
Antiseptics
Burns and scalds
Care and treatment
Chlorine
Collagen
Effectiveness
Electrolytic cells
Evaluation
Growth factors
Health aspects
Horizontal orientation
Hydrogels
Infections
Inflammation
Intervention
Ketamine
Laboratory animals
Parameters
Scald
Skin
Sulfadiazine
Tissue engineering
Wound healing
Wounds and injuries
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Summary:Burn injuries impose challenges such as infection risk, pain management, fluid loss, electrolyte imbalance and psychological and emotional impact, on healthcare professionals, requiring effective treatments to enhance wound healing. The present study evaluated the efficacy superoxidized electrolyzed solution (SES), with low (SES-low) or high (SES-high) concentrations of active species, alone or in combination with a formulation in gel (G), in comparison with commonly prescribed treatments for burn injury, including nitrofurazone (NF) and silver sulfadiazine (S); normal saline was used as placebo (PI). A scald burn model was established in BALB/c mice. Measurements of the burned area and histological parameters such as inflammatory infiltration state, epithelial regeneration and collagen fibers were evaluated on days 3, 6, 9, 18 and 32 to assess healing score and status. All treatments achieved wound closure at day 32; histopathological parameters indicated that SES-low and SES-low + G performed better than the Pl and S groups (P
ISSN:2049-9434
2049-9442
2049-9442
DOI:10.3892/br.2024.1877