effect of starvation and refeeding on lipogenic enzymes in mammary glands and livers of lactating rats

Lactating rats were starved for 48 h and refed a high-carbohydrate diet for a further 48 h. Starvation stops milk secretion, which resumes shortly after refeeding. Three lipogenic enzymes, fatty acid synthase, glucose 6-phosphate dehydrogenase (EC 1.1.1.49) and 'malic' enzyme (EC 1.1.1.40)...

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Bibliographic Details
Published in:Biochemical journal 1983-11, Vol.216 (2), p.515-518
Main Authors: Grigor, M.R, Gain, K.R
Format: Article
Language:English
Subjects:
Animals
diet-related diseases
Fatty Acid Synthases - metabolism
Female
Food
Glucosephosphate Dehydrogenase - metabolism
human nutrition
Lactation
Liver - enzymology
Malate Dehydrogenase - metabolism
Mammary Glands, Animal - enzymology
Pregnancy
Rats
Rats, Inbred Strains
Starvation - enzymology
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Summary:Lactating rats were starved for 48 h and refed a high-carbohydrate diet for a further 48 h. Starvation stops milk secretion, which resumes shortly after refeeding. Three lipogenic enzymes, fatty acid synthase, glucose 6-phosphate dehydrogenase (EC 1.1.1.49) and 'malic' enzyme (EC 1.1.1.40) all decrease in the mammary gland during starvation and are restored to the pre-starvation levels 48 h after refeeding. The same enzymes in liver also decrease during starvation, but increase to values significantly higher than those for the normal fed rats after refeeding the high-carbohydrate diet. For the fatty acid synthase these values were four times the pre-starvation values. Serum insulin and prolactin concentrations also increased upon refeeding the high-carbohydrate diet.
ISSN:0306-3283
0264-6021
1470-8728
DOI:10.1042/bj2160515