β-Cyclodextrin/Zn-Fe layered double hydroxides/graphitic carbon nitride nanomaterials based potentiometric sensor for paroxetine determination in environmental water samples

Developing targeted and sensitive analytical techniques for drug monitoring in different specimens are of utmost importance. Herein, a first attempt was made for the determination of paroxetine (Prx + ) in environmental water samples using a novel, sensitive, selective, stable, accurate and eco-frie...

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Bibliographic Details
Published in:RSC advances 2024-10, Vol.14 (47), p.34791-3483
Main Authors: Ashry, Ahmed, Rabia, Mohamed, Mostafa, Sahar Mahmoud, Korany, Mohamed Ali, Farghali, Ahmed Ali, Khalil, Mohamed Magdy
Format: Article
Language:English
Subjects:
Carbon
Carbon nitride
Chemistry
Cyclodextrins
Dibutyl phthalate
Electrochemical impedance spectroscopy
Hydroxides
Nanomaterials
Sensors
Surface properties
Thermal stability
Water sampling
Zinc
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Summary:Developing targeted and sensitive analytical techniques for drug monitoring in different specimens are of utmost importance. Herein, a first attempt was made for the determination of paroxetine (Prx + ) in environmental water samples using a novel, sensitive, selective, stable, accurate and eco-friendly potentiometric sensor based on Zn-Fe layered double hydroxides/graphitic carbon nitride (Zn-Fe LDH/g-C 3 N 4 ) nanomaterials with β-cyclodextrin (β-CD) as the sensing ionophore and dibutyl phthalate (DBP) as the plasticizer. The prepared nanomaterial was characterized using X-ray diffraction (XRD) and scanning electron microscopy (SEM). The surface properties of the proposed sensor were characterized by electrochemical impedance spectroscopy (EIS). The sensor exhibited an excellent Nernstian slope of 59.3 ± 0.7 mV decade −1 covering a wide linear working range of 1.0 × 10 −6 to 1.0 × 10 −2 mol L −1 , low detection limit of 3.0 × 10 −7 mol L −1 , low quantification limit of 9.9 × 10 −7 mol L −1 , long life time, sufficient selectivity, high chemical and thermal stability within a wide pH range of 2.0-9.0. This analytical method was successfully implemented for Prx + determination in a pure form, pharmaceutical formulation and different water samples. Developing targeted and sensitive analytical techniques for drug monitoring in different specimens are of utmost importance.
ISSN:2046-2069
2046-2069
DOI:10.1039/d4ra03863k