Thermogenic and lipogenic activities in brown adipose tissue of I-strain mice

The thermogenic capacity of brown adipose tissue has been investigated in I-strain mice to determine whether this tissue could play a role in the lower efficiency of food utilization reported in this strain of mice. (1) As compared with C57BL mice (a control strain), interscapular-brown-adipose-tiss...

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Bibliographic Details
Published in:Biochemical journal 1985-11, Vol.231 (3), p.761-764
Main Authors: Bazin, R, Ricquier, D, Dupuy, F, Hoover-Plow, J, Lavau, M
Format: Article
Language:English
Subjects:
Adipose Tissue, Brown - enzymology
Adipose Tissue, Brown - metabolism
Animals
ATP Citrate (pro-S)-Lyase - metabolism
Fatty Acid Synthases - metabolism
Hot Temperature
Lipids - biosynthesis
Malate Dehydrogenase - metabolism
Male
Mice
Mice, Inbred Strains
Mitochondria - metabolism
Proteins - metabolism
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Summary:The thermogenic capacity of brown adipose tissue has been investigated in I-strain mice to determine whether this tissue could play a role in the lower efficiency of food utilization reported in this strain of mice. (1) As compared with C57BL mice (a control strain), interscapular-brown-adipose-tissue weight and lipid percentage were decreased by 40% and 13% respectively in I-strain mice. (2) Mitochondrial protein content and cytochrome c oxidase activity were similar in the two strains, but the number of mitochondrial GDP-binding sites and uncoupling-protein content were increased by 2-fold in I-strain mice. (3) Fatty acid synthetase and citrate-cleavage enzyme (units/mg of protein) were 3-fold higher in the brown adipose tissue of I-strain mice. These results indicate that I-strain mice possess a very active brown adipose tissue. This enhanced capacity of energy dissipation in brown adipose tissue could contribute to the decreased capacity of I-strain mice to store adipose tissue.
ISSN:0264-6021
1470-8728
DOI:10.1042/bj2310761