Prognostic nomogram model based on quantitative metrics of subregions surrounding residual cavity in glioblastoma patients

• Published in: Journal of cancer research and clinical oncology 2024-11, Vol.150 (11), p.483, Article 483
• Main Authors: Gao, Lijuan, Yuan, Tao, Liu, Yawu, Yang, Xiaoyun, Li, Yiming, Quan, Guanmin
• Format: Article
• Language: English
• Subjects: Adult; Aged; Brain Neoplasms - diagnostic imaging; Brain Neoplasms - pathology; Brain Neoplasms - therapy; Cancer Research; Chemoradiotherapy; Corpus callosum; Decision making; Female; Glioblastoma; Glioblastoma - diagnostic imaging; Glioblastoma - pathology; Glioblastoma - surgery; Glioblastoma - therapy; Glioma; Hematology; Humans; Internal Medicine; Magnetic Resonance Imaging - methods; Male; Medicine; Medicine & Public Health; Middle Aged; Neoplasm Recurrence, Local - diagnostic imaging; Neoplasm Recurrence, Local - pathology; Neoplasm, Residual - pathology; Nomograms; Oncology; Patients; Prognosis; Retrospective Studies; Subventricular zone
• ISSN: 1432-1335; 0171-5216; 1432-1335
• DOI: 10.1007/s00432-024-06008-6

Background The hyperintensity area surrounding the residual cavity on postoperative fluid-attenuated inversion recovery (FLAIR) image is a potential site for glioblastoma (GBM) recurrence. This study aimed to develop a nomogram using quantitative metrics from subregions of this area, prior to chemoradiotherapy (CRT), to predict early GBM recurrence. Methods Adult patients with GBM diagnosed between October 2018 and October 2022 were retrospectively analyzed. Quantitative metrics, including the mean, maximum, minimum, median values, and standard deviation of FLAIR signal intensity (SI) (measured using 3D-Slicer software), were extracted from the following subregions surrounding the residual cavity on post-contrast T1-weighted (CE-T1WI)-FLAIR fusion images: the enhancing region (ER), non-enhancing region (NER), and combined ER + NER. Independent prognostic factors were identified using Cox regression and least absolute shrinkage and selection operator (LASSO) analyses and were incorporated into the prediction nomogram model. The model’s performance was evaluated using the C-index, calibration curves, and decision curves. Results A total of 129 adult GBM patients were enrolled and randomly assigned to a training (n = 90) and a validation cohorts (n = 39) in a 7:3 ratio. Sixty-nine patients experienced postoperative recurrence. Cox regression analysis identified subventricular zone involvement, the median FLAIR intensity in the ER, the rFLAIR (relative FLAIR intensity compared to the contralateral normal region) of ER + NER, and corpus callosum involvement as independent prognostic factors. For predicting recurrence within 1 year after surgery, the nomogram model had a C-index of 0.733 in the training cohort and 0.746 in the validation cohort. Based on the nomogram score, post-operative GBM patients could be stratified into high- and low-risk for recurrence. Conclusions Nomogram models which based on quantitative metrics from FLAIR hyperintensity subregions may serve as potential markers for assessing GBM recurrence risk. This approach could enhance clinical decision-making and provide an alternative method for recurrence estimation in GBM patients.