Embryonic size and growth and adverse birth outcomes: the Rotterdam Periconception Cohort

Is early embryonic size and growth in the first trimester of pregnancy associated with adverse birth outcomes? Larger embryonic crown-rump length (CRL) and embryonic volume (EV) are associated with lower odds of adverse birth outcomes, especially small for gestational age (SGA). Preterm birth, SGA,...

Full description

Saved in:
Bibliographic Details
Published in:Human reproduction (Oxford) 2024-11, Vol.39 (11), p.2434-2441
Main Authors: Roelants, J A, Vermeulen, M J, Willemsen, S P, Been, J V, Koning, A H, Eggink, A J, Joosten, K F M, Reiss, I K M, Steegers-Theunissen, R P M
Format: Article
Language:English
Subjects:
Adult
Cohort Studies
Congenital Abnormalities - diagnostic imaging
Congenital Abnormalities - epidemiology
Crown-Rump Length
Embryonic Development
Female
Gestational Age
Humans
Infant, Newborn
Infant, Small for Gestational Age
Netherlands - epidemiology
Original
Pregnancy
Pregnancy Outcome - epidemiology
Pregnancy Trimester, First
Premature Birth - epidemiology
Prospective Studies
Ultrasonography, Prenatal
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Is early embryonic size and growth in the first trimester of pregnancy associated with adverse birth outcomes? Larger embryonic crown-rump length (CRL) and embryonic volume (EV) are associated with lower odds of adverse birth outcomes, especially small for gestational age (SGA). Preterm birth, SGA, and congenital anomalies are the most prevalent adverse birth outcomes with lifelong health consequences as well as high medical and societal costs. In the late first and second trimesters of pregnancy, fetuses at risk for adverse birth outcomes can be identified using 2-dimensional ultrasonography (US). Between 2009 and 2018, singleton pregnancies were enrolled in this ongoing prospective Rotterdam Periconception Cohort. This study included 918 pregnant women from a tertiary hospital in the Netherlands. Pregnancy dating was based on either a regular menstrual cycle (for natural pregnancies) or a conception date (for ART pregnancies). CRL and EV were measured using Virtual Reality software on 3-dimensional (3D) ultrasound scans, repeatedly performed around 7, 9, and 11 weeks of gestation. The main outcome measure was adverse birth outcome, defined as the composite of SGA (birth weight
ISSN:0268-1161
1460-2350
1460-2350
DOI:10.1093/humrep/deae212