Transfer of intestine-derived diamines into tumour cells during treatment of Ehrlich-ascites--carcinoma-bearing mice with polyamine anti-metabolites

Treatment of Ehrlich-ascites-carcinoma-bearing mice with methylglyoxal bis(guanylhydrazone) alone or in combination with 2-difluoromethylornithine greatly enhanced the transfer of intragastrically administered radioactive putrescine and cadaverine into the carcinoma cells. Difluoromethylornithine al...

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Bibliographic Details
Published in:Biochemical journal 1984-03, Vol.218 (2), p.641-644
Main Authors: Kallio, A, Nikula, P, Jänne, J
Format: Article
Language:English
Subjects:
Animals
Cadaverine - metabolism
Carcinoma, Ehrlich Tumor - metabolism
Diamines - metabolism
Eflornithine
Guanidines - pharmacology
Mice
Mitoguazone - pharmacology
Ornithine - analogs & derivatives
Ornithine - pharmacology
Putrescine - metabolism
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Summary:Treatment of Ehrlich-ascites-carcinoma-bearing mice with methylglyoxal bis(guanylhydrazone) alone or in combination with 2-difluoromethylornithine greatly enhanced the transfer of intragastrically administered radioactive putrescine and cadaverine into the carcinoma cells. Difluoromethylornithine alone did not have any effect on the accumulation of intestine-derived diamines in the tumour cells. The frequently reported restoration of difluoromethylornithine-induced polyamine depletion on administration of methylglyoxal bis(guanylhydrazone) is in all likelihood attributable to a profound inhibition of intestinal diamine oxidase (EC 1.4.3.6), resulting in an enhanced entry of intestinal (bacterial) diamines into general circulation and finally into tumour cells.
ISSN:0264-6021
1470-8728
DOI:10.1042/bj2180641