Loading…

A Primary Health Care Program and COVID-19. Impact in Hospital Admissions and Mortality

Most patients with mild or moderate COVID infection did not require hospital admission, but depending on their personal history, they needed medical supervision. In monitoring these patients in primary care, the design of specific surveillance programs was of great help. Between February 2021 and Ma...

Full description

Saved in:
Bibliographic Details
Published in:Journal of general internal medicine : JGIM 2024-11, Vol.39 (14), p.2662-2670
Main Authors: García-Marichal, Cristina, Aguilar-Jerez, Manuel Francisco, Delgado-Plasencia, Luciano Jonathan, Pérez-Hernández, Onán, Armas-González, José Fernando, Pelazas-González, Ricardo, Martín-González, Candelaria
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c312t-e5eeb45d8b9e588f51988b8757c8c5c13ee10cf9ae34bc49b67617d53b34152d3
container_end_page 2670
container_issue 14
container_start_page 2662
container_title Journal of general internal medicine : JGIM
container_volume 39
creator García-Marichal, Cristina
Aguilar-Jerez, Manuel Francisco
Delgado-Plasencia, Luciano Jonathan
Pérez-Hernández, Onán
Armas-González, José Fernando
Pelazas-González, Ricardo
Martín-González, Candelaria
description Most patients with mild or moderate COVID infection did not require hospital admission, but depending on their personal history, they needed medical supervision. In monitoring these patients in primary care, the design of specific surveillance programs was of great help. Between February 2021 and March 2022, EDCO program was designed in Tenerife, Spain, to telemonitor patients with COVID infection who had at least one vulnerability factor to reduce hospital admissions and mortality. The aim of this study is to describe the clinical course of patients included in the EDCO program and to analyze which factors were associated with a higher probability of hospital admission and mortality. Retrospective cohort study. We included 3848 patients with a COVID-19 infection age over 60 years old or age over 18 years and at least one vulnerability factor previously reported in medical history. Primary outcome was to assess risk of admission or mortality. 278 (7.2%) patients required hospital admission. Relative risks (RR) of hospital admission were oxygen saturation ≤ 92% (RR: 90.91 (58.82-142.86)), respiratory rate ≥ 22 breaths per minute (RR: 20.41 (1.19-34.48), obesity (RR: 1.53 (1.12-2.10), chronic kidney disease (RR:2.31 (1.23-4.35), ≥ 60 years of age (RR: 1.44 (1.04-1.99). Mortality rate was 0.7% (27 patients). Relative risks of mortality were respiratory rate ≥ 22 breaths per minute (RR: 24.85 (11.15-55.38), patients with three or more vulnerability factors (RR: 4.10 (1.62-10.38), oxygen saturation ≤ 92% (RR: 4.69 (1.70-15.15), chronic respiratory disease (RR: 3.32 (1.43-7.69) and active malignancy (RR: 4.00 (1.42-11.23). Vulnerable patients followed by a primary care programme had admission rates of 7.2% and mortality rates of 0.7%. Supervision of vulnerable patients by a Primary Care team was effective in the follow-up of these patients with complete resolution of symptoms in 91.7% of the cases.
doi_str_mv 10.1007/s11606-024-08912-6
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11535086</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3123926312</sourcerecordid><originalsourceid>FETCH-LOGICAL-c312t-e5eeb45d8b9e588f51988b8757c8c5c13ee10cf9ae34bc49b67617d53b34152d3</originalsourceid><addsrcrecordid>eNpdkc1qGzEUhUVpaBwnL9BFEXTTjRxdaaSRVsW4aWxwSBb5WQqNRk4mzIxcaRzI21f-aWiyunB1dLgfH0JfgU6A0vI8AUgqCWUFoUoDI_ITGoFggkChy89oRJUqiCp5cYxOUnqmFDhj6gs65poyLiUboYcpvolNZ-MrnnvbDk94ZqPPu_AYbYdtX-PZ9f3iFwE9wYtubd2Amx7PQ1o3g23xtO6alJrQp132KsS8bYbXU3S0sm3yZ4c5Rne_L25nc7K8vlzMpkviOLCBeOF9VYhaVdoLpVYCtFKVKkXplBMOuPdA3Upbz4vKFbqSpYSyFrziRSat-Rj93PeuN1Xna-f7IdrWrPdMJtjGvH_pmyfzGF4MgOCCKpkbfhwaYviz8Wkwmcj5trW9D5tkOFWMAyiqcvT7h-hz2MQ-85lMwzWT2zFGbJ9yMaQU_ertGqBmK87sxZkszuzEme0V3_7nePvyzxT_C5kLkig</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3123926312</pqid></control><display><type>article</type><title>A Primary Health Care Program and COVID-19. Impact in Hospital Admissions and Mortality</title><source>Springer Nature</source><creator>García-Marichal, Cristina ; Aguilar-Jerez, Manuel Francisco ; Delgado-Plasencia, Luciano Jonathan ; Pérez-Hernández, Onán ; Armas-González, José Fernando ; Pelazas-González, Ricardo ; Martín-González, Candelaria</creator><creatorcontrib>García-Marichal, Cristina ; Aguilar-Jerez, Manuel Francisco ; Delgado-Plasencia, Luciano Jonathan ; Pérez-Hernández, Onán ; Armas-González, José Fernando ; Pelazas-González, Ricardo ; Martín-González, Candelaria</creatorcontrib><description>Most patients with mild or moderate COVID infection did not require hospital admission, but depending on their personal history, they needed medical supervision. In monitoring these patients in primary care, the design of specific surveillance programs was of great help. Between February 2021 and March 2022, EDCO program was designed in Tenerife, Spain, to telemonitor patients with COVID infection who had at least one vulnerability factor to reduce hospital admissions and mortality. The aim of this study is to describe the clinical course of patients included in the EDCO program and to analyze which factors were associated with a higher probability of hospital admission and mortality. Retrospective cohort study. We included 3848 patients with a COVID-19 infection age over 60 years old or age over 18 years and at least one vulnerability factor previously reported in medical history. Primary outcome was to assess risk of admission or mortality. 278 (7.2%) patients required hospital admission. Relative risks (RR) of hospital admission were oxygen saturation ≤ 92% (RR: 90.91 (58.82-142.86)), respiratory rate ≥ 22 breaths per minute (RR: 20.41 (1.19-34.48), obesity (RR: 1.53 (1.12-2.10), chronic kidney disease (RR:2.31 (1.23-4.35), ≥ 60 years of age (RR: 1.44 (1.04-1.99). Mortality rate was 0.7% (27 patients). Relative risks of mortality were respiratory rate ≥ 22 breaths per minute (RR: 24.85 (11.15-55.38), patients with three or more vulnerability factors (RR: 4.10 (1.62-10.38), oxygen saturation ≤ 92% (RR: 4.69 (1.70-15.15), chronic respiratory disease (RR: 3.32 (1.43-7.69) and active malignancy (RR: 4.00 (1.42-11.23). Vulnerable patients followed by a primary care programme had admission rates of 7.2% and mortality rates of 0.7%. Supervision of vulnerable patients by a Primary Care team was effective in the follow-up of these patients with complete resolution of symptoms in 91.7% of the cases.</description><identifier>ISSN: 0884-8734</identifier><identifier>ISSN: 1525-1497</identifier><identifier>EISSN: 1525-1497</identifier><identifier>DOI: 10.1007/s11606-024-08912-6</identifier><identifier>PMID: 39023662</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Aged ; Aged, 80 and over ; COVID-19 ; COVID-19 - epidemiology ; COVID-19 - mortality ; COVID-19 - therapy ; Design factors ; Female ; Health care ; Health risks ; Hospitalization - statistics &amp; numerical data ; Hospitals ; Humans ; Infections ; Kidney diseases ; Male ; Malignancy ; Middle Aged ; Mortality ; Mortality risk ; Original Research ; Oxygen ; Oxygen content ; Oxygen saturation ; Patient admissions ; Patients ; Primary care ; Primary Health Care - organization &amp; administration ; Respiration ; Respiratory diseases ; Respiratory rate ; Retrospective Studies ; Risk assessment ; SARS-CoV-2 ; Spain - epidemiology ; Telemedicine</subject><ispartof>Journal of general internal medicine : JGIM, 2024-11, Vol.39 (14), p.2662-2670</ispartof><rights>2024. The Author(s).</rights><rights>Copyright Springer Nature B.V. Nov 2024</rights><rights>The Author(s) 2024 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c312t-e5eeb45d8b9e588f51988b8757c8c5c13ee10cf9ae34bc49b67617d53b34152d3</cites><orcidid>0000-0002-4702-1840</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39023662$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>García-Marichal, Cristina</creatorcontrib><creatorcontrib>Aguilar-Jerez, Manuel Francisco</creatorcontrib><creatorcontrib>Delgado-Plasencia, Luciano Jonathan</creatorcontrib><creatorcontrib>Pérez-Hernández, Onán</creatorcontrib><creatorcontrib>Armas-González, José Fernando</creatorcontrib><creatorcontrib>Pelazas-González, Ricardo</creatorcontrib><creatorcontrib>Martín-González, Candelaria</creatorcontrib><title>A Primary Health Care Program and COVID-19. Impact in Hospital Admissions and Mortality</title><title>Journal of general internal medicine : JGIM</title><addtitle>J Gen Intern Med</addtitle><description>Most patients with mild or moderate COVID infection did not require hospital admission, but depending on their personal history, they needed medical supervision. In monitoring these patients in primary care, the design of specific surveillance programs was of great help. Between February 2021 and March 2022, EDCO program was designed in Tenerife, Spain, to telemonitor patients with COVID infection who had at least one vulnerability factor to reduce hospital admissions and mortality. The aim of this study is to describe the clinical course of patients included in the EDCO program and to analyze which factors were associated with a higher probability of hospital admission and mortality. Retrospective cohort study. We included 3848 patients with a COVID-19 infection age over 60 years old or age over 18 years and at least one vulnerability factor previously reported in medical history. Primary outcome was to assess risk of admission or mortality. 278 (7.2%) patients required hospital admission. Relative risks (RR) of hospital admission were oxygen saturation ≤ 92% (RR: 90.91 (58.82-142.86)), respiratory rate ≥ 22 breaths per minute (RR: 20.41 (1.19-34.48), obesity (RR: 1.53 (1.12-2.10), chronic kidney disease (RR:2.31 (1.23-4.35), ≥ 60 years of age (RR: 1.44 (1.04-1.99). Mortality rate was 0.7% (27 patients). Relative risks of mortality were respiratory rate ≥ 22 breaths per minute (RR: 24.85 (11.15-55.38), patients with three or more vulnerability factors (RR: 4.10 (1.62-10.38), oxygen saturation ≤ 92% (RR: 4.69 (1.70-15.15), chronic respiratory disease (RR: 3.32 (1.43-7.69) and active malignancy (RR: 4.00 (1.42-11.23). Vulnerable patients followed by a primary care programme had admission rates of 7.2% and mortality rates of 0.7%. Supervision of vulnerable patients by a Primary Care team was effective in the follow-up of these patients with complete resolution of symptoms in 91.7% of the cases.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>COVID-19</subject><subject>COVID-19 - epidemiology</subject><subject>COVID-19 - mortality</subject><subject>COVID-19 - therapy</subject><subject>Design factors</subject><subject>Female</subject><subject>Health care</subject><subject>Health risks</subject><subject>Hospitalization - statistics &amp; numerical data</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infections</subject><subject>Kidney diseases</subject><subject>Male</subject><subject>Malignancy</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Mortality risk</subject><subject>Original Research</subject><subject>Oxygen</subject><subject>Oxygen content</subject><subject>Oxygen saturation</subject><subject>Patient admissions</subject><subject>Patients</subject><subject>Primary care</subject><subject>Primary Health Care - organization &amp; administration</subject><subject>Respiration</subject><subject>Respiratory diseases</subject><subject>Respiratory rate</subject><subject>Retrospective Studies</subject><subject>Risk assessment</subject><subject>SARS-CoV-2</subject><subject>Spain - epidemiology</subject><subject>Telemedicine</subject><issn>0884-8734</issn><issn>1525-1497</issn><issn>1525-1497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNpdkc1qGzEUhUVpaBwnL9BFEXTTjRxdaaSRVsW4aWxwSBb5WQqNRk4mzIxcaRzI21f-aWiyunB1dLgfH0JfgU6A0vI8AUgqCWUFoUoDI_ITGoFggkChy89oRJUqiCp5cYxOUnqmFDhj6gs65poyLiUboYcpvolNZ-MrnnvbDk94ZqPPu_AYbYdtX-PZ9f3iFwE9wYtubd2Amx7PQ1o3g23xtO6alJrQp132KsS8bYbXU3S0sm3yZ4c5Rne_L25nc7K8vlzMpkviOLCBeOF9VYhaVdoLpVYCtFKVKkXplBMOuPdA3Upbz4vKFbqSpYSyFrziRSat-Rj93PeuN1Xna-f7IdrWrPdMJtjGvH_pmyfzGF4MgOCCKpkbfhwaYviz8Wkwmcj5trW9D5tkOFWMAyiqcvT7h-hz2MQ-85lMwzWT2zFGbJ9yMaQU_ertGqBmK87sxZkszuzEme0V3_7nePvyzxT_C5kLkig</recordid><startdate>20241101</startdate><enddate>20241101</enddate><creator>García-Marichal, Cristina</creator><creator>Aguilar-Jerez, Manuel Francisco</creator><creator>Delgado-Plasencia, Luciano Jonathan</creator><creator>Pérez-Hernández, Onán</creator><creator>Armas-González, José Fernando</creator><creator>Pelazas-González, Ricardo</creator><creator>Martín-González, Candelaria</creator><general>Springer Nature B.V</general><general>Springer International Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-4702-1840</orcidid></search><sort><creationdate>20241101</creationdate><title>A Primary Health Care Program and COVID-19. Impact in Hospital Admissions and Mortality</title><author>García-Marichal, Cristina ; Aguilar-Jerez, Manuel Francisco ; Delgado-Plasencia, Luciano Jonathan ; Pérez-Hernández, Onán ; Armas-González, José Fernando ; Pelazas-González, Ricardo ; Martín-González, Candelaria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c312t-e5eeb45d8b9e588f51988b8757c8c5c13ee10cf9ae34bc49b67617d53b34152d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>COVID-19</topic><topic>COVID-19 - epidemiology</topic><topic>COVID-19 - mortality</topic><topic>COVID-19 - therapy</topic><topic>Design factors</topic><topic>Female</topic><topic>Health care</topic><topic>Health risks</topic><topic>Hospitalization - statistics &amp; numerical data</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Infections</topic><topic>Kidney diseases</topic><topic>Male</topic><topic>Malignancy</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Mortality risk</topic><topic>Original Research</topic><topic>Oxygen</topic><topic>Oxygen content</topic><topic>Oxygen saturation</topic><topic>Patient admissions</topic><topic>Patients</topic><topic>Primary care</topic><topic>Primary Health Care - organization &amp; administration</topic><topic>Respiration</topic><topic>Respiratory diseases</topic><topic>Respiratory rate</topic><topic>Retrospective Studies</topic><topic>Risk assessment</topic><topic>SARS-CoV-2</topic><topic>Spain - epidemiology</topic><topic>Telemedicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>García-Marichal, Cristina</creatorcontrib><creatorcontrib>Aguilar-Jerez, Manuel Francisco</creatorcontrib><creatorcontrib>Delgado-Plasencia, Luciano Jonathan</creatorcontrib><creatorcontrib>Pérez-Hernández, Onán</creatorcontrib><creatorcontrib>Armas-González, José Fernando</creatorcontrib><creatorcontrib>Pelazas-González, Ricardo</creatorcontrib><creatorcontrib>Martín-González, Candelaria</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of general internal medicine : JGIM</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>García-Marichal, Cristina</au><au>Aguilar-Jerez, Manuel Francisco</au><au>Delgado-Plasencia, Luciano Jonathan</au><au>Pérez-Hernández, Onán</au><au>Armas-González, José Fernando</au><au>Pelazas-González, Ricardo</au><au>Martín-González, Candelaria</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Primary Health Care Program and COVID-19. Impact in Hospital Admissions and Mortality</atitle><jtitle>Journal of general internal medicine : JGIM</jtitle><addtitle>J Gen Intern Med</addtitle><date>2024-11-01</date><risdate>2024</risdate><volume>39</volume><issue>14</issue><spage>2662</spage><epage>2670</epage><pages>2662-2670</pages><issn>0884-8734</issn><issn>1525-1497</issn><eissn>1525-1497</eissn><abstract>Most patients with mild or moderate COVID infection did not require hospital admission, but depending on their personal history, they needed medical supervision. In monitoring these patients in primary care, the design of specific surveillance programs was of great help. Between February 2021 and March 2022, EDCO program was designed in Tenerife, Spain, to telemonitor patients with COVID infection who had at least one vulnerability factor to reduce hospital admissions and mortality. The aim of this study is to describe the clinical course of patients included in the EDCO program and to analyze which factors were associated with a higher probability of hospital admission and mortality. Retrospective cohort study. We included 3848 patients with a COVID-19 infection age over 60 years old or age over 18 years and at least one vulnerability factor previously reported in medical history. Primary outcome was to assess risk of admission or mortality. 278 (7.2%) patients required hospital admission. Relative risks (RR) of hospital admission were oxygen saturation ≤ 92% (RR: 90.91 (58.82-142.86)), respiratory rate ≥ 22 breaths per minute (RR: 20.41 (1.19-34.48), obesity (RR: 1.53 (1.12-2.10), chronic kidney disease (RR:2.31 (1.23-4.35), ≥ 60 years of age (RR: 1.44 (1.04-1.99). Mortality rate was 0.7% (27 patients). Relative risks of mortality were respiratory rate ≥ 22 breaths per minute (RR: 24.85 (11.15-55.38), patients with three or more vulnerability factors (RR: 4.10 (1.62-10.38), oxygen saturation ≤ 92% (RR: 4.69 (1.70-15.15), chronic respiratory disease (RR: 3.32 (1.43-7.69) and active malignancy (RR: 4.00 (1.42-11.23). Vulnerable patients followed by a primary care programme had admission rates of 7.2% and mortality rates of 0.7%. Supervision of vulnerable patients by a Primary Care team was effective in the follow-up of these patients with complete resolution of symptoms in 91.7% of the cases.</abstract><cop>United States</cop><pub>Springer Nature B.V</pub><pmid>39023662</pmid><doi>10.1007/s11606-024-08912-6</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-4702-1840</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0884-8734
ispartof Journal of general internal medicine : JGIM, 2024-11, Vol.39 (14), p.2662-2670
issn 0884-8734
1525-1497
1525-1497
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11535086
source Springer Nature
subjects Aged
Aged, 80 and over
COVID-19
COVID-19 - epidemiology
COVID-19 - mortality
COVID-19 - therapy
Design factors
Female
Health care
Health risks
Hospitalization - statistics & numerical data
Hospitals
Humans
Infections
Kidney diseases
Male
Malignancy
Middle Aged
Mortality
Mortality risk
Original Research
Oxygen
Oxygen content
Oxygen saturation
Patient admissions
Patients
Primary care
Primary Health Care - organization & administration
Respiration
Respiratory diseases
Respiratory rate
Retrospective Studies
Risk assessment
SARS-CoV-2
Spain - epidemiology
Telemedicine
title A Primary Health Care Program and COVID-19. Impact in Hospital Admissions and Mortality
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T14%3A03%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20Primary%20Health%20Care%20Program%20and%20COVID-19.%20Impact%20in%20Hospital%20Admissions%20and%20Mortality&rft.jtitle=Journal%20of%20general%20internal%20medicine%20:%20JGIM&rft.au=Garc%C3%ADa-Marichal,%20Cristina&rft.date=2024-11-01&rft.volume=39&rft.issue=14&rft.spage=2662&rft.epage=2670&rft.pages=2662-2670&rft.issn=0884-8734&rft.eissn=1525-1497&rft_id=info:doi/10.1007/s11606-024-08912-6&rft_dat=%3Cproquest_pubme%3E3123926312%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c312t-e5eeb45d8b9e588f51988b8757c8c5c13ee10cf9ae34bc49b67617d53b34152d3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=3123926312&rft_id=info:pmid/39023662&rfr_iscdi=true