Changes in 24-hour blood pressure profile after 12 weeks of dapagliflozin treatment in patients with diabetic kidney disease: an Italian multicenter prospective study

ABSTRACT Background Sodium-glucose cotransporter 2 inhibitors (SGLT2i) lower ambulatory blood pressure (ABP) in patients with type 2 diabetes mellitus; whether the same holds true in diabetic kidney disease (DKD) is unknown. This information is critical to the knowledge of mechanisms of nephroprotec...

Full description

Saved in:
Bibliographic Details
Published in:Clinical kidney journal 2024-11, Vol.17 (11), p.sfae316
Main Authors: Borrelli, Silvio, Garofalo, Carlo, Reboldi, Gianpaolo, Coppola, Annapaola, Chiodini, Paolo, Simeoni, Mariadelina, Mazzieri, Alessio, Volpe, Luca Della, Gallieni, Maurizio, Zummo, Carola, Cottone, Santina, Ravera, Maura, Aucella, Filippo, Aucella, Francesco, Stallone, Giovanni, Gismondi, Valeria, Alberici, Federico, Gregori, Marco, Castellano, Giuseppe, Vettoretti, Simone, Cozzolino, Mario, Ruotolo, Chiara, Minutolo, Roberto, De Nicola, Luca
Format: Article
Language:English
Subjects:
Blood pressure
Dapagliflozin
Diabetic nephropathies
Dosage and administration
Drug therapy
Hypertension
Original
Physiological aspects
Prevention
Regulation
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:ABSTRACT Background Sodium-glucose cotransporter 2 inhibitors (SGLT2i) lower ambulatory blood pressure (ABP) in patients with type 2 diabetes mellitus; whether the same holds true in diabetic kidney disease (DKD) is unknown. This information is critical to the knowledge of mechanisms of nephroprotection and safety of this therapy. Methods This multicenter prospective study evaluates the changes in ABP after 12 weeks of dapagliflozin 10 mg/day in a cohort of patients with type 2 DKD and glomerular filtration rate (GFR) >25 mL/min/1.73 m2. Primary endpoint was the change of nighttime systolic blood pressure (SBP). Changes of daytime SBP, prevalence of normal dipping (day/night SBP ratio
ISSN:2048-8505
2048-8513
DOI:10.1093/ckj/sfae316