Naamidine A reveals a promising zinc-binding strategy for topical antifungal therapy

Fungal disease affects over a billion people worldwide. Naamidine A inhibits the growth of diverse fungal pathogens through an unknown mechanism. Here, we show that the supplementation of medium with excess zinc abolishes the antifungal activity of naamidine A. Furthermore, we highlight that naamidi...

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Bibliographic Details
Published in:Antimicrobial agents and chemotherapy 2024-11, Vol.68 (11), p.e0119424
Main Authors: Puumala, Emily, Nabeela, Sunna, Thornburg, Christopher C, Grkovic, Tanja, Uppuluri, Priya, Whitesell, Luke, O'Keefe, Barry R, Robbins, Nicole, Cowen, Leah E
Format: Article
Language:English
Subjects:
Administration, Topical
Animals
Antifungal Agents - pharmacology
Antifungal Agents - therapeutic use
Arthrodermataceae
Clinical Therapeutics
Dermatomycoses - drug therapy
Disease Models, Animal
Drug Resistance, Fungal - drug effects
Humans
Mice
Microbial Sensitivity Tests
Mycology
Terbinafine - pharmacology
Terbinafine - therapeutic use
Tinea - drug therapy
Tinea - microbiology
Trichophyton - drug effects
Zinc
Citations: Items that this one cites
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Summary:Fungal disease affects over a billion people worldwide. Naamidine A inhibits the growth of diverse fungal pathogens through an unknown mechanism. Here, we show that the supplementation of medium with excess zinc abolishes the antifungal activity of naamidine A. Furthermore, we highlight that naamidine A has activity against terbinafine-resistant . and efficacy in a mouse model of dermatomycosis caused by highlighting its therapeutic potential as a topical treatment.
ISSN:0066-4804
1098-6596
1098-6596
DOI:10.1128/aac.01194-24