WHO global research priorities for antimicrobial resistance in human health

• Published in: The Lancet. Microbe 2024-11, Vol.5 (11), p.100902-None, Article 100902
• Main Authors: Bertagnolio, Silvia, Olaru, Ioana Diana, Chaillon, Antoine, Hasso-Agopsowicz, Mateusz, Kothari, Kavita U, Cassini, Alessandro, Hamers, Raph L, Weezenbeek, Kitty Van, Alanio, Alexandre, Alemayehu, Tinsae, Al-Maani, Amal Saif, Applegate, Tanya, Araj, George F, Årdal, Christine, Ashiru-Oredope, Diane, Ashley, Elizabeth A, Baquero, Fernando, Bassat, Quique, Bassetti, Matteo, Berkley, James A, Bines, Julie, Bradley, John S, Brett, Ana, Buising, Kirsty, Cavaleri, Marco, Chabala, Chishala, Chakrabarti, Arunaloke, Chiara, Francesca, Coffin, Susan E, Cooper, Ben, Darton, Tom, de Egea, Viviana, Denkinger, Claudia, Dillon, Jo-Anne R, Dramowski, Angela, Roberta Esposito, Susanna Maria, Essack, Sabiha Y, Farida, Helmia, Farooqi, Joveria, Fifer, Helen, Finlayson, Heather, Giske, Christian, Guessennd, Nathalie, Gurbanova, Elmira, Heim, Jutta, Hope, William, Ismail, Ghada, Issack, Mohammad Iqbal, Jehan, Fyeza, Pearson, Antonieta Jimenez, Kolho, Kaija-Leena, Kontoyiannis, Dimitrios P, Kranzer, Katharina, Lahra, Monica M, Lass-Flörl, Cornelia, Lodha, Rakesh, Lye, David Chien, Mahmud, Asif Mujtaba, Manaia, Célia, Mareković, Ivana, Morel, Chantal, Mueller, Arno, Ndow, Francis J, Obaro, Stephen, Okomo, Uduak, Ortellado de Canese, Juana Medarda, Pai, Madhukar, Park, Benjamin, Parkhill, Julian, Parry, Christopher M, Reddy, Denasha Lavanya, Reddy, Kessendri, Rodríguez Tudela, Juan Luis, Rollier, Christine, Ronat, Jean-Baptiste, Salisbury, David, Salou, Mounerou, Sartelli, Massimo, Schellack, Natalie, Schouten, Jeroen, Shakoor, Sadia, Sievert, Dawn, Singla, Rupak, Srinivasan, Arjun, Srinivasan, Subasree, Tacconelli, Evelina, Tahseen, Sabira, Tootla, Hafsah Deepa, Tsioutis, Constantinos, Omar, Shaheed Vally, van de Sande, Wendy WJ, van den Hof, Susan, van Doorn, Rogier, Wang, Hui, Warris, Adilia, Weinstock, Hillard, Williams, Phoebe, Moscoso, Martin Yagui, Yu, Yunsong, Rudan, Igor
• Format: Article
• Language: English
• Subjects: Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - therapeutic use; Bacterial Infections - drug therapy; Bacterial Infections - epidemiology; Bacterial Infections - microbiology; Drug Resistance, Bacterial; Drug Resistance, Microbial; Global Health; Humans; Review; World Health Organization
• ISSN: 2666-5247; 2666-5247
• DOI: 10.1016/S2666-5247(24)00134-4

The WHO research agenda for antimicrobial resistance (AMR) in human health has identified 40 research priorities to be addressed by the year 2030. These priorities focus on bacterial and fungal pathogens of crucial importance in addressing AMR, including drug-resistant pathogens causing tuberculosis. These research priorities encompass the entire people-centred journey, covering prevention, diagnosis, and treatment of antimicrobial-resistant infections, in addition to addressing the overarching knowledge gaps in AMR epidemiology, burden and drivers, policies and regulations, and awareness and education. The research priorities were identified through a multistage process, starting with a comprehensive scoping review of knowledge gaps, with expert inputs gathered through a survey and open call. The priority setting involved a rigorous modified Child Health and Nutrition Research Initiative approach, ensuring global representation and applicability of the findings. The ultimate goal of this research agenda is to encourage research and investment in the generation of evidence to better understand AMR dynamics and facilitate policy translation for reducing the burden and consequences of AMR.