Dopamine in Sports: A Narrative Review on the Genetic and Epigenetic Factors Shaping Personality and Athletic Performance

• Published in: International journal of molecular sciences 2024-11, Vol.25 (21), p.11602
• Main Author: Humińska-Lisowska, Kinga
• Format: Article
• Language: English
• Subjects: Athletes; Athletic Performance - psychology; Cognition & reasoning; Cognitive ability; Decision making; DNA methylation; Dopamine; Dopamine - genetics; Dopamine - metabolism; Epigenesis, Genetic; Epigenetics; Gene-Environment Interaction; Genes; Genetic aspects; Health aspects; Human performance; Humans; Impulsivity; Influence; Personality; Personality - genetics; Personality traits; Physiological aspects; Physiology; Polymorphism, Single Nucleotide; Psychological aspects; Review; Single nucleotide polymorphisms; Sport science; Success; Well being
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms252111602

This narrative review examines the relationship between dopamine-related genetic polymorphisms, personality traits, and athletic success. Advances in sports genetics have identified specific single nucleotide polymorphisms (SNPs) in dopamine-related genes linked to personality traits crucial for athletic performance, such as motivation, cognitive function, and emotional resilience. This review clarifies how genetic variations can influence athletic predisposition through dopaminergic pathways and environmental interactions. Key findings reveal associations between specific SNPs and enhanced performance in various sports. For example, polymorphisms such as Val158Met rs4680 and Val66Met rs6265 are associated with traits that could benefit performance, such as increased focus, stress resilience and conscientiousness, especially in martial arts. rs167771 is associated with higher agreeableness, benefiting teamwork in sports like football. This synthesis underscores the multidimensional role of genetics in shaping athletic ability and advocates for integrating genetic profiling into personalized training to optimize performance and well-being. However, research gaps remain, including the need for standardized training protocols and exploring gene-environment interactions in diverse populations. Future studies should focus on how genetic and epigenetic factors can inform tailored interventions to enhance both physical and psychological aspects of athletic performance. By bridging genetics, personality psychology, and exercise science, this review paves the way for innovative training and performance optimization strategies.