Hemoperfusion with CytoSorb ® in Pediatric Patients: A Monocentric Case Series

Pro- and anti-inflammatory cytokines help regulate the inflammatory response. A cytokine storm is a dysregulated cytokine response associated with sepsis and other conditions that result in a hyper-inflammatory state. Extracorporeal cytokine adsorption has the potential to restore a balanced inflamm...

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Bibliographic Details
Published in:Journal of clinical medicine 2024-11, Vol.13 (21), p.6587
Main Authors: Rihar, Eva, Peršič, Vanja, Jerman, Alexander, Plankar Srovin, Tina, Mlakar, Gorazd, Bezeljak, Neva, Pokorn, Marko, Fister, Petja
Format: Article
Language:English
Subjects:
Adsorbents
Adsorption
Care and treatment
Critically ill children
Cytokine storm
Dialysate
Extracorporeal membrane oxygenation
Graft versus host disease
Hemodialysis
Hemodynamics
Hemoperfusion
Inflammation
Intensive care
Methods
Mortality
Patients
Pediatric research
Pediatrics
Renal replacement therapy
Sepsis
Tumor necrosis factor-TNF
Ventilators
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Summary:Pro- and anti-inflammatory cytokines help regulate the inflammatory response. A cytokine storm is a dysregulated cytokine response associated with sepsis and other conditions that result in a hyper-inflammatory state. Extracorporeal cytokine adsorption has the potential to restore a balanced inflammatory response. Hemoperfusion with CytoSorb (CS) appears to be a short-term mode of treatment of sepsis in both adults and children. We present a case series of eight critically ill children involving the use of hemoperfusion with CS at the University Medical Center Ljubljana to treat clinically manifested cytokine storm. In our preliminary experience, it was applied without complication in five children weighing more than 10 kg, who all survived. The effect of age on complications regarding CS treatment is unclear, yet in our case series, all three patients weighing less than 10 kg died of their disease. In our preliminary experience, cytokine adsorption with CS remains a potential adjunctive treatment for cytokine storm in critically ill children.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm13216587