Mitigating Dietary Bisphenol Exposure Through the Gut Microbiota: The Role of Next-Generation Probiotics in Bacterial Detoxification

Bisphenols, such as bisphenol A and its analogs, which include bisphenol S, bisphenol F, bisphenol AF, and tetramethyl bisphenol F, are chemical contaminants commonly found in food that raise serious health concerns. These xenobiotics can potentially have harmful effects on human health. The gut mic...

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Bibliographic Details
Published in:Nutrients 2024-10, Vol.16 (21), p.3757
Main Authors: Emanowicz, Paulina, Średnicka, Paulina, Wójcicki, Michał, Roszko, Marek, Juszczuk-Kubiak, Edyta
Format: Article
Language:English
Subjects:
Adipocytes
Adults
Animals
Benzhydryl Compounds
Beverages
Bisphenol A
Chemical contaminants
Chemicals
Dietary Exposure - adverse effects
Food
Food Contamination
Food contamination & poisoning
Food packaging
Gastrointestinal Microbiome - drug effects
Health aspects
Heavy metals
Homeostasis
Hormones
Humans
Inactivation, Metabolic
Metabolic disorders
Microbiota
Microbiota (Symbiotic organisms)
Obesity
Pesticides
Phenols
Probiotics
Probiotics - administration & dosage
Review
Safety and security measures
Stem cells
Urine
Xenobiotics
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Summary:Bisphenols, such as bisphenol A and its analogs, which include bisphenol S, bisphenol F, bisphenol AF, and tetramethyl bisphenol F, are chemical contaminants commonly found in food that raise serious health concerns. These xenobiotics can potentially have harmful effects on human health. The gut microbiota plays a crucial role in metabolizing and neutralizing these substances, which is essential for their detoxification and elimination. Probiotic supplementation has been studied for its ability to modulate the gut microbiota's composition and function, enhancing detoxification processes. Next-Generation Probiotics (NGPs) may exhibit better properties than traditional strains and are designed for targeted action on specific conditions, such as obesity. By modulating inflammatory responses and reducing the secretion of pro-inflammatory cytokines, they can significantly improve host health. Research on NGPs' ability to neutralize obesogenic bisphenols remains limited, but their potential makes this a promising area for future exploration. This review aims to understand the mechanisms of the chemical transformation of bisphenol through its interactions with the gut microbiota and the role of probiotics, particularly NGPs, in these processes. Understanding the interplay between bisphenols, gut microbiota, and NGPs may pave the way for strategies to counteract the negative health effects associated with daily and chronic exposure to bisphenols, which is crucial for food safety and consumer health protection.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu16213757