The Excellent Chemical Interaction Properties of Poloxamer and Pullulan with Alpha Mangostin on Amorphous Solid Dispersion System: Molecular Dynamics Simulation

Alpha mangostin (AM) has demonstrated significant potential as an anticancer agent, owing to its potent bioactivity. However, its clinical application is limited by poor solubility, which hampers its bioavailability and effectiveness. Amorphous solid dispersion (ASD) presents a promising technique t...

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Published in:Polymers 2024-10, Vol.16 (21), p.3065
Main Authors: Rusdin, Agus, Muchtaridi, Muchtaridi, Megantara, Sandra, Wardhana, Yoga Windhu, Fakih, Taufik Muhammad, Budiman, Arif
Format: Article
Language:English
Subjects:
Bioavailability
Breast cancer
Cancer
Cancer therapies
Care and treatment
Chemical bonds
Comparative analysis
Cooling
Cooling rate
Effectiveness
Hydrogen
Hydrogen bonding
Ligands
Molecular dynamics
Molecular structure
Optimization
Poloxamers
Polymers
Polysaccharides
Prostate
Pullulan
Simulation
Simulation methods
Software
Solubility
Stability
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container_title Polymers
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Muchtaridi, Muchtaridi
Megantara, Sandra
Wardhana, Yoga Windhu
Fakih, Taufik Muhammad
Budiman, Arif
description Alpha mangostin (AM) has demonstrated significant potential as an anticancer agent, owing to its potent bioactivity. However, its clinical application is limited by poor solubility, which hampers its bioavailability and effectiveness. Amorphous solid dispersion (ASD) presents a promising technique to enhance the solubility and stability of AM. Molecular dynamics simulation offers a rapid, efficient, and precise method to evaluate and optimize ASD formulations before production. In this study, we conducted molecular dynamics simulations to explore the ASD development of AM with poloxamer and pullulan. Our results revealed that AM-poloxamer complexes exhibit superior interaction characteristics compared to AM-pullulan, with a 1:5 ratio of AM to poloxamer and a cooling rate of 1 °C/ns demonstrating the most favorable outcomes. This combination showed enhanced hydrogen bonding, a more compact molecular structure, and higher stability, making it the optimal choice for ASD formulation. The integration of molecular dynamics simulation into ASD development significantly accelerates the formulation process and provides critical insights into achieving a stable and effective AM dispersion. The AM-poloxamer complex, particularly at a 1:5 ratio with a 1 °C/ns cooling rate, offers the best potential for improving AM solubility and therapeutic efficacy.
doi_str_mv 10.3390/polym16213065
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subjects Bioavailability
Breast cancer
Cancer
Cancer therapies
Care and treatment
Chemical bonds
Comparative analysis
Cooling
Cooling rate
Effectiveness
Hydrogen
Hydrogen bonding
Ligands
Molecular dynamics
Molecular structure
Optimization
Poloxamers
Polymers
Polysaccharides
Prostate
Pullulan
Simulation
Simulation methods
Software
Solubility
Stability
title The Excellent Chemical Interaction Properties of Poloxamer and Pullulan with Alpha Mangostin on Amorphous Solid Dispersion System: Molecular Dynamics Simulation
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