Anticancer potential of phytochemicals derived from mangrove plants: Comprehensive mechanistic insights

• Published in: Food science & nutrition 2024-09, Vol.12 (9), p.6174-6205
• Main Authors: Chowdhury, Raihan, Bhuia, Md. Shimul, Al Hasan, Md. Sakib, Hossain Snigdha, Shadid, Afrin, Sadia, Büsselberg, Dietrich, Habtemariam, Solomon, Sönmez Gürer, Eda, Sharifi‐Rad, Javad, Ahmed Aldahish, Afaf, Аkhtayeva, Nursulu, Islam, Muhammad Torequl
• Format: Article
• Language: English
• Subjects: anticancer phytochemicals; Anticancer properties; Antineoplastic drugs; Antitumor activity; Antitumor agents; Apoptosis; Autophagy; Biocompatibility; Biological activity; Biological effects; cancer; Cancer therapies; Cell cycle; Chemotherapy; Cytotoxicity; Drug development; Genotoxicity; Herbal medicine; Immunomodulation; In vivo methods and tests; mangrove plants; Mangroves; Medicinal plants; Metastasis; molecular mechanisms; Molecular modelling; Morbidity; Neuroprotection; Oxidative stress; Phytochemicals; Plant layout; Respiration; Review; Side effects; Toxicity testing; Well being
• ISSN: 2048-7177; 2048-7177
• DOI: 10.1002/fsn3.4318

Cancer is a collection of illnesses characterized by aberrant cellular proliferation that can infiltrate or metastasize to distant anatomical sites, posing a notable threat to human well‐being due to its substantial morbidity and death rates worldwide. The potential of plant‐derived natural compounds as anticancer medicines has been assessed owing to their favorable attributes of few side effects and significant antitumor activity. Mangrove plants and their derived compounds have been scientifically shown to exhibit many significant beneficial biological activities, such as anti‐inflammatory, immunomodulatory, antioxidant, neuroprotective, cardioprotective, and hepatoprotective properties. This study summarized mangrove plants and their derived compounds as potential anticancer agents, with an emphasis on the underlying molecular mechanisms. To explore this, we gathered data on the preclinical (in vivo and in vitro) anticancer effects of mangrove plants and their derived compounds from reputable literature spanning 2000 to 2023. We conducted thorough searches in various academic databases, including PubMed, ScienceDirect, Wiley Online, SpringerLink, Google Scholar, Scopus, and the Web of Science. The results demonstrated that mangrove plants and their derived compounds have promising anticancer properties in preclinical pharmacological test systems through various molecular mechanisms, including induction of oxidative stress and mitochondrial dysfunction, cytotoxicity, genotoxicity, cell cycle arrest, apoptosis, autophagy, antiproliferative, antimetastatic, and other miscellaneous actions. Upon thorough observation of the pertinent information, it is suggested that mangrove plants and their derived chemicals may serve as a potential lead in the development of novel drugs for cancer therapy. The primary goal of the present study was to evaluate the anticancer abilities of mangrove plants and their compounds in great detail. In addition, we seek to investigate the molecular processes that give rise to mangrove plants and their phytochemical anticancer properties, focusing on their possible application in cancer treatment, which could provide valuable insights for future investigations and the development of novel therapeutic approaches.