Update on cutaneous mesenchymal tumors in the 5th edition of WHO classification of skin tumors with an emphasis on new fusion-associated neoplasms

The section on mesenchymal tumors in the 5th edition of WHO classification of skin tumors has undergone several changes, the most important of which is the inclusion of newly identified tumor entities, which will be the main focus of this review article. These specifically include three novel cutane...

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Bibliographic Details
Published in:Virchows Archiv : an international journal of pathology 2024-11, Vol.485 (5), p.777-792
Main Authors: Kalmykova, Antonina V., Baranovska-Andrigo, Vira, Michal, Michael
Format: Article
Language:English
Subjects:
Actin
CD34 antigen
Classification
FLI-1 protein
Humans
Medicine
Medicine & Public Health
Neoplasms
Oncogene Proteins, Fusion - genetics
Pathology
Review
Skin Neoplasms - classification
Skin Neoplasms - genetics
Skin Neoplasms - pathology
Smad3 protein
Tumors
World Health Organization
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Summary:The section on mesenchymal tumors in the 5th edition of WHO classification of skin tumors has undergone several changes, the most important of which is the inclusion of newly identified tumor entities, which will be the main focus of this review article. These specifically include three novel cutaneous mesenchymal tumors with melanocytic differentiation, and rearrangements of the CRTC1::TRIM11 , ACTIN::MITF , and MITF::CREM genes as well as EWSR1::SMAD3 -rearranged fibroblastic tumors, superficial CD34-positive fibroblastic tumors, and NTRK -rearranged spindle cell neoplasms. Some of the other most important changes will be briefly mentioned as well.
ISSN:0945-6317
1432-2307
1432-2307
DOI:10.1007/s00428-024-03925-2