Estrogen and psychosis — a review and future directions

The link between sex hormones and schizophrenia has been suspected for over a century; however, scientific evidence supporting the pharmacotherapeutic effects of exogenous estrogen has only started to emerge during the past three decades. Accumulating evidence from epidemiological and basic research...

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Bibliographic Details
Published in:Archives of women's mental health 2024-12, Vol.27 (6), p.877-885
Main Authors: Mu, Eveline, Gurvich, Caroline, Kulkarni, Jayashri
Format: Article
Language:English
Subjects:
Drug therapy
Epidemiology
Estrogen receptors
Estrogen Replacement Therapy
Estrogens
Female
Humans
Medicine
Medicine & Public Health
Mental disorders
Psychiatry
Psychosis
Psychotherapy
Psychotic Disorders - drug therapy
Review
Review Article
Schizophrenia
Schizophrenia - drug therapy
Selective estrogen receptor modulators
Selective Estrogen Receptor Modulators - therapeutic use
Sex hormones
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Summary:The link between sex hormones and schizophrenia has been suspected for over a century; however, scientific evidence supporting the pharmacotherapeutic effects of exogenous estrogen has only started to emerge during the past three decades. Accumulating evidence from epidemiological and basic research suggests that estrogen has a protective effect in women vulnerable to schizophrenia. Such evidence has led multiple researchers to investigate the role of estrogen in schizophrenia and its use in treatment. This narrative review provides an overview of the effects of estrogen as well as summarizes the recent work regarding estrogen as a treatment for schizophrenia, particularly the use of new-generation selective estrogen receptor modulators.
ISSN:1434-1816
1435-1102
1435-1102
DOI:10.1007/s00737-023-01409-x