Intraocular pressure, primary open-angle glaucoma and the risk of retinal vein occlusion: A Mendelian randomization mediation analysis

Background The etiological connection between intraocular pressure (IOP) and the risk of retinal vein occlusion (RVO) remains elusive, particularly regarding whether this risk emanates from the direct influence of elevated intraocular pressure (IOP), irrespective of the presence of primary open-angl...

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Bibliographic Details
Published in:Eye (London) 2024-12, Vol.38 (17), p.3347-3351
Main Authors: Katsimpris, Andreas, Baumeister, Sebastian-Edgar, Voulgari, Nafsika, Baurecht, Hansjörg, Kandarakis, Stylianos, Nolde, Michael
Format: Article
Language:English
Subjects:
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692/499
692/699/3161/3175
Aged
Complications
Female
Genetic Predisposition to Disease
Genome-wide association studies
Genome-Wide Association Study
Glaucoma
Glaucoma, Open-Angle - genetics
Humans
Intraocular Pressure - physiology
Laboratory Medicine
Male
Mediation Analysis
Medicine
Medicine & Public Health
Mendelian Randomization Analysis
Middle Aged
Occlusion
Ophthalmology
Pharmaceutical Sciences/Technology
Pleiotropy
Polymorphism, Single Nucleotide
Retina
Retinal Vein Occlusion - epidemiology
Retinal Vein Occlusion - genetics
Risk Factors
Single-nucleotide polymorphism
Surgery
Surgical Oncology
United Kingdom - epidemiology
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Summary:Background The etiological connection between intraocular pressure (IOP) and the risk of retinal vein occlusion (RVO) remains elusive, particularly regarding whether this risk emanates from the direct influence of elevated intraocular pressure (IOP), irrespective of the presence of primary open-angle glaucoma (POAG), or if it arises as a consequence of the sequelae of POAG. Therefore, we conducted a Mendelian Randomization (MR) mediation analysis to elucidate the mediating role of POAG in the association between IOP and RVO. Methods We identified 47 single-nucleotide polymorphisms (SNPs) associated with IOP ( P -value 
ISSN:0950-222X
1476-5454
1476-5454
DOI:10.1038/s41433-024-03303-x